首页> 外国专利> Correlation ratio of mRNA expression levels of thymidine phosphorylase and dihydropyrimidine dehydrogenase in colorectal cancer with disease-free survival in patients treated with 5-FU.

Correlation ratio of mRNA expression levels of thymidine phosphorylase and dihydropyrimidine dehydrogenase in colorectal cancer with disease-free survival in patients treated with 5-FU.

机译：5-FU治疗的大肠癌中胸苷磷酸化酶和二氢嘧啶脱氢酶的mRNA表达水平与无病生存的相关性。

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摘要

A method for determining whether a patient suffering from colorectal cancer is susceptible to treatment with 5-fluorouracil and / or analogs 5-Fluorouracil comprising the following steps: a) determining the mRNA expression of thymidine phosphorylase in a sample clinical b) determining mRNA expression dehydrogenase dihidripirimidina in said clinical sample c) determination of the ratio value obtained in step a) and the value obtained in step b) d) determination whether the ratio obtained in step c) exceeds a predetermined cutoff value

机译：一种确定患有大肠癌的患者是否对5-氟尿嘧啶和/或类似物5-氟尿嘧啶敏感的方法，其包括以下步骤：a）在临床样品中确定胸苷磷酸化酶的mRNA表达b）确定mRNA表达脱氢酶所述临床样品中的双嘧达西胺（dhidripirimidina）c）确定在步骤a）中获得的比率值和在步骤b）中获得的值d）确定在步骤c）中获得的比率是否超过预定的临界值

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公开/公告号ES2279266T3

专利类型
公开/公告日2007-08-16

原文格式PDF
申请/专利权人 F. HOFFMANN-LA ROCHE AG;
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申请/专利号ES20040020100T
发明设计人 LUTZ VERENA DR.;KRAUSE FRIEDMANN DR.;POIGNEE-HEGER MANUELA DR.;WALTER THOMAS DR.;PORSTMANN BAERBEL PROF. DR.;WERNER MARTIN PROF. DR.;
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申请日2004-08-25
分类号C12N15/09;C12Q1/68;
国家 ES
入库时间 2022-08-21 20:54:25

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