首页> 外国专利> A POLYPEPTIDE CODING MOLECULE OF THE NUCLEIC ACID, HUMAN GROWTH PROTEIN CODED BY THE DNA MOLECULE, HUMAN GROWTH PROTEIN CODING CDNA, PHARMACEUTICAL COMPOUND, APPLICATION OF HUMAN GROWTH PROTEIN AND THE DNA SEQUENCE, METHOD FOR THE DETERMINATION OF THE LOW GROWTH, METHOD FOR THE IDENTIFICATION OF THE GENETIC DEFECT, CELLS TRANSFORMED BY THE DNA SEQUENCE, TESTING SYSTEM AND METHOD FOR THE IDENTIFICATION OR SCREENING TESTS, EXPRESSION VECTOR AS WELL AS APPLICATION OF THE HUMAN GROWTH PROTEINS

A POLYPEPTIDE CODING MOLECULE OF THE NUCLEIC ACID, HUMAN GROWTH PROTEIN CODED BY THE DNA MOLECULE, HUMAN GROWTH PROTEIN CODING CDNA, PHARMACEUTICAL COMPOUND, APPLICATION OF HUMAN GROWTH PROTEIN AND THE DNA SEQUENCE, METHOD FOR THE DETERMINATION OF THE LOW GROWTH, METHOD FOR THE IDENTIFICATION OF THE GENETIC DEFECT, CELLS TRANSFORMED BY THE DNA SEQUENCE, TESTING SYSTEM AND METHOD FOR THE IDENTIFICATION OR SCREENING TESTS, EXPRESSION VECTOR AS WELL AS APPLICATION OF THE HUMAN GROWTH PROTEINS

机译：核酸的多肽编码分子，由DNA分子编码的人类生长蛋白质，人类生长蛋白质编码CDNA，药物化合物，人类生长蛋白质和DNA序列的应用，低生长度的测定方法，方法基因缺陷，DNA序列转化的细胞，鉴定或筛选试验的表达系统和方法，表达载体以及人类生长蛋白的应用

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摘要

An isolated human nucleic acid molecule (I) encodes polypeptides containing a homeobox domain of 60 amino acids (sequence given in the specification) that have regulatory activity on human growth. Also claimed are: (1) a DNA sequence comprising the nucleotide sequence (NS) of SHOX (short stature homeobox-containing) ET93, i.e. exon II of the SHOX gene (209 bp sequence given in the specification); (2) a DNA sequence comprising the NS of SHOX ET92 (753 bp sequence given in the specification); (3) a human growth protein selected from SHOXa, SHOXb and SHOT and functional fragments of these (292, 225 and 190 amino acid sequences, respectively, given in the specification)) having an amino acid sequence as shown or a functional fragment; (4) a cDNA encoding a protein as in (3); (5) a transgenic animal transformed with a gene responsible for short stature that comprises (I) or a DNA molecule as in (1) or (2); (6) cells transformed with (I) or a DNA molecule as in (1) or (2); (7) a functional expression vector comprising (I); and (8) antibodies obtained by immunisation of mammals using transcription factors A, B or C (i.e. SHOXa, SHOXb and SHOT) or antigenic fragments and isolating such antibodies from such mammals.

机译：分离的人核酸分子（I）编码含有对人的生长具有调节活性的60个氨基酸的同源框结构域（在说明书中给出的序列）的多肽。还要求保护：（1）一种DNA序列，其包含SHOX（含短身同源盒）ET93的核苷酸序列（NS），即SHOX基因的外显子II（说明书中给出的209bp序列）; （2）包含SHOX ET92的NS的DNA序列（说明书中给出的753bp序列）; （3）选自SHOXa，SHOXb和SHOT的人类生长蛋白及其功能片段（在说明书中分别给出292、225和190个氨基酸序列），其具有所示的氨基酸序列或功能片段; （4）编码（3）中的蛋白质的cDNA。（5）用负责（1）或（1）或（2）的DNA分子的矮身形基因转化的转基因动物; （6）用（I）或如（1）或（2）所述的DNA分子转化的细胞; （7）包含（I）的功能性表达载体。（8）通过使用转录因子A，B或C（即SHOXa，SHOXb和SHOT）或抗原片段对哺乳动物进行免疫并从此类哺乳动物中分离出此类抗体而获得的抗体。

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公开/公告号PL194248B1

专利类型
公开/公告日2007-05-31

原文格式PDF
申请/专利权人 RAPPOLD-HOERBRAND GUDRUN;
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申请/专利号PL19970332568
发明设计人 RAPPOLD-HOERBRAND GUDRUN;RAO ERCOLE;
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申请日1997-09-29
分类号A01K67/027;C12N15/12;A61K31/7088;A61K38;A61K38/17;A61K38/18;A61K38/22;A61K45;A61K48;A61P3;A61P5/02;A61P5/06;C07K14/47;C07K14/475;C07K16/18;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12Q1/02;C12Q1/68;
国家 PL
入库时间 2022-08-21 20:56:41

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