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Macrolonas

机译：马克龙

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摘要

Refers to a compound of formula I where z is alquileno C3 C6, alquenileno C3 C6, or alquinileno C3 C6; r1 is formula (ii) where ra is H or c1-c6 alkyl, cycloalkyl, RX is C3 C6 C1 - C6 alkyl cicloalquil C3, C1 - C6 alkyl - C3, among others; ry is H OR Halogen; R2 is H,A hydroxyl Protecting Group; R3 is h; R4 is Hydroxy or alkoxy; alqueniloxi C3 C6 C1 - C6; R5 is Hydroxy; R6 h; n is a Group - (R7) - CH2 - Bivalent or - ch2n (R7); R7 is H or c1-c6 alkyl; is 2 - 5.Preferred compounds are: 4 '- O - (3 - [3 - (dimethylamino) - 1 - 3 - Carboxy - 4 - oxo - 1,4 - dihydro - quinolin-1 - 6 - il) - prop - 2 - in - 1 - iloxi}] - propyl - azithromycin; 4' - O - (3 - [3 - (dimethylamino) - 1 - 3 - Carboxy - 4 - oxo - 1,4 - dihydro - quinolin-1 - 6 - il) - prop - 2 - iniloxi}] - propyl - azithromycin; among others. Refers to a Pharmaceutical Composition and a preparation method.The described compounds have Antimicrobial activity and are useful in the Treatment or prophylaxis of systemic or topical microbial infections

机译：指式I的化合物，其中z为alquileno C3 C6，alquenileno C3 C6或alquinileno C3 C6; r1是式（ii），其中ra是H或C1-C6烷基，环烷基，RX是C3，C6，C1-C6烷基环氯基C3，C1-C6烷基-C3等。 ry是氢或卤素; R 2为H，A羟基保护基; R3为h; R4是羟基或烷氧基; Alqueniloxi C3 C6 C1-C6; R5是羟基; R6小时; n是基团-（R7）-CH2-二价或-ch2n（R7）; R7是H或C1-C6烷基;是2-5。首选化合物为：4'-O-（3-[3-（二甲氨基）-1-3-羧基-4-羰基-1,4-二氢-喹啉-1-6-il）-丙-2-在-1-伊洛西}]-丙基-阿奇霉素; 4'-O-（3-[3-（二甲基氨基）-1-3-羧基-4-氧代-1,4-二氢-喹啉-1-6-il）-prop-2-iniloxi}]-丙基-阿奇霉素其中。指药物组合物和制备方法。所描述的化合物具有抗菌活性，可用于治疗或预防全身或局部微生物感染

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公开/公告号PE07182007A1

专利类型
公开/公告日2007-07-18

原文格式PDF
申请/专利权人 GLAXO GROUP LIMITED;GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGEB D. O. O.;
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申请/专利号PE20060001378
发明设计人 PALEJ IVANA;KAPIC SAMRA;BERGE JOHN MICHAEL;FRYDRYCH CATHERINE SIMONE VICTOIRE;ALIHODZIC SULEJMAN;
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申请日2006-11-07
分类号A61K31/706;A61P31/04;C07H17/08;
国家 PE
入库时间 2022-08-21 20:56:42

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