首页> 外国专利> LSA-5 LIVER STAGE AND BLOOD STAGE ANTIGEN OF PLASMODIUM FALCIPARUM, IMMUNOGENIC COMPOSITION COMPRISING SAID ANTIGEN AND VACCINES AGAINST MALARIA.

LSA-5 LIVER STAGE AND BLOOD STAGE ANTIGEN OF PLASMODIUM FALCIPARUM, IMMUNOGENIC COMPOSITION COMPRISING SAID ANTIGEN AND VACCINES AGAINST MALARIA.

机译：恶性疟原虫的LSA-5肝阶段和血液阶段抗原，包含抗疟疾的所说的抗原和疫苗的免疫原性成分。

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摘要

The present invention pertains to the protection against malaria. More particularly, the invention is based on the characterization of a novel liver and sporozoite-stage P.falciparum antigen, referred to as LSA-5. This antigen is highly antigenic and the prevalence of antibodies in subjects living in endemic areas is extremely high (ca. 90 %). The invention concerns antigenic peptides, mixtures thereof, or polypeptides, mixotopes and conjugates comprising part of the sequence of LSA-5, as well as im-munogenic compositions, vaccines and kits comprising these.

机译：本发明涉及预防疟疾。更具体地，本发明基于新型肝和子孢子阶段恶性疟原虫抗原的表征，称为LSA-5。该抗原是高度抗原性的，并且抗体在流行地区的受试者中患病率非常高（约90％）。本发明涉及包含LSA-5序列的一部分的抗原肽，其混合物或多肽，混合物和缀合物，以及包含它们的免疫原性组合物，疫苗和试剂盒。

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公开/公告号IN2006DN03411A

专利类型
公开/公告日2007-08-31

原文格式PDF
申请/专利权人
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申请/专利号IN3411/DELNP/2006
发明设计人 DRUILHE PIERRE;BRAHIMI ZEGHIDOUR KARIMA;
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申请日2006-06-13
分类号C07K16/44;A61K35/16;C07K7/08;A61K39/39;C12N15/63;C07K16/20;C12P21/08;A61K31/7088;G01N33/569;C07K14/00;C07K7/06;C12N1/15;A61P33/06;C12N1/21;C07H21/04;A61K39/395;C12N15/09;C12N5/10;C07K17/02;C07K17/00;A61K39/15;A61K39/02;C12N1/19;G01N33/50;C40B40/10;G01N33/53;C07K14/445;
国家 IN
入库时间 2022-08-21 20:57:54

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