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POLYMERIC CONJUGATE OF INTERFERON-β MODIFICATIONS, PHARMACEUTICAL PRODUCTS ON ITS BASIS AND METHOD OF OBTAINING THEM
POLYMERIC CONJUGATE OF INTERFERON-β MODIFICATIONS, PHARMACEUTICAL PRODUCTS ON ITS BASIS AND METHOD OF OBTAINING THEM
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机译：干扰素-β修饰的聚合物缀合物，医药产品的制备依据及获得方法
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摘要
Methods for the synthesis of polymeric conjugates of cytokines and their receptor-binding antagonists, especially non-glycosylated interferon-β, are presented, and the conjugates retain an unusually high biological activity. The preparation of polymer conjugates according to the methods of this invention minimizes or avoids steric inhibition of receptor-ligand interactions, which is usually the result of the addition of polymers to the receptor-binding sites of cytokines, as well as their agonistic and antagonistic analogues. The invention also provides conjugates and compositions prepared by these methods. Conjugates corresponding to this invention, retain a high level of biological activity compared with the traditional methods of binding polymers, which are not intended to avoid the receptor-binding domains of cytokines. In in vitro assays, the biological activity of the conjugates of non-glycosylated interferon-β according to the invention is significantly higher than that of unconjugated interferon-β and close to the activity of interferon-β, which is glycosylated. Conjugates corresponding to this invention also exhibit an increased half-life in vivo in comparison with the corresponding unconjugated cytokine. The invention also provides kits containing these conjugates and / or compositions, and methods of using such conjugates and compositions in a variety of diagnostic, prophylactic, and therapeutic applications and bioprocessing, including the treatment of multiple sclerosis.
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