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use of ncsag4 gene diagnosis and prevention of neosporosis and as a marker for pathogenesis analysis

机译:ncsag4基因在诊断和预防新孢子虫病中的应用,以及作为发病机理分析的标志

摘要

"NcSAG4 GENE USE FOR DIAGNOSIS AND NEOSPOROSIS PREVENTION AND AS A PAPER MARKER PATHOGENESIS ANALYSIS". The invention relates to the NcSAG4 gene, the RNA messenger of said gene, oligonucleotides designed for the nucleotide sequence thereof or any fragment thereof, and the NcSAG4 protein encoded by it or any of the recombinant forms thereof. expression vectors and host cells containing the same for the purpose of diagnosis and vaccination for the prevention of neospore. The invention also relates to its use as a specific marker of N. caninum bradyzoite stage for the analysis of pathogenesis or efficacy of vaccines against the establishment of a chronic infection in the intermediate host.
机译:“ NcSAG4基因用于诊断和新骨质疏松症的预防,以及作为纸牌病原菌分析的依据”。本发明涉及NcSAG4基因,该基因的RNA信使,为其核苷酸序列或其任何片段设计的寡核苷酸,以及由其编码的NcSAG4蛋白或其任何重组形式。表达载体和包含它们的宿主细胞,用于诊断和预防新孢子的疫苗接种。本发明还涉及其用作犬新孢子虫缓殖子阶段的特异性标记物的用途,用于分析疫苗的发病机理或针对中间宿主中慢性感染的建立的功效。

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