首页> 外国专利> human 21 fibroblast growth factor mutant (fgf-21), or a biologically active peptide thereof, polynucleotide, expression vector, host cell, process for producing a polypeptide, pharmaceutical composition, method for treating a patient, and, use da muteìna fgf-21

human 21 fibroblast growth factor mutant (fgf-21), or a biologically active peptide thereof, polynucleotide, expression vector, host cell, process for producing a polypeptide, pharmaceutical composition, method for treating a patient, and, use da muteìna fgf-21

机译:人21成纤维细胞生长因子突变体(fgf-21)或其生物活性肽,多核苷酸,表达载体,宿主细胞,多肽的制备方法,药物组合物,治疗患者的方法以及使用fgf-21突变体

摘要

"MUTEIN OF HUMAN 21 FIBROBLAST GROWTH FACTOR (FGF-21), OR A BIOLOGICALLY ACTIVE PEPTIDE, POLYNUCLEOTIDE, EXPRESSION VECTOR, HOST CELL, PROCESS TO PRODUCE A POLYPETHYETE PATIOTE, A COMPETARY PHYTETEIUM, USING THE FGF-21 MUTEIN ". The present invention relates to novel human fibroblast growth factor muteins 21 with improved pharmaceutical properties. Both proteins and respective coding nucleic acid species are described. The invention also relates to vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Methods for treating type 2 diabetes, obesity, metabolic syndrome, and for reducing mortality and morbidity of critically ill patients are also described.
机译:“人类21成纤维细胞生长因子(FGF-21)的蛋白,或具有生物活性的肽,多核苷酸,表达载体,宿主细胞,使用FGF-21突变蛋白生产多肽型,竞争性植物。本发明涉及具有改善的药物特性的新型人成纤维细胞生长因子突变蛋白21。描述了蛋白质和相应的编码核酸种类。本发明还涉及用于所述核酸序列的繁殖和所述突变蛋白的产生的载体和宿主细胞。还描述了用于治疗2型糖尿病,肥胖,代谢综合症以及降低危重患者死亡率和发病率的方法。

著录项

  • 公开/公告号BRPI0416683A

    专利类型

  • 公开/公告日2007-01-30

    原文格式PDF

  • 申请/专利权人 ELI LILLY AND COMPANY;

    申请/专利号BR2004PI16683

  • 发明设计人

    申请日2004-12-01

  • 分类号C12N15/12;C12N1/19;C07K14/50;A61K38/18;

  • 国家 BR

  • 入库时间 2022-08-21 20:59:26

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