首页> 外国专利> composition, bacterium or preparation thereof, method for detecting the presence of an a / e pathogen in a sample, method for eliciting an immune response against an a / e pathogen or a component thereof in an animal, method for reducing colonization of a / e pathogen in an animal, method for reducing the spread of an a / e pathogen in an animal, method for treating or preventing infection by an a / e pathogen, method for attenuating virulence of a / e pathogen, method for selecting a compound that mitigates the virulence of a pathogen and a / e, method for producing an a / e pathogen polypeptide, recombinant polypeptide, isolated nucleic acid molecule , vector, host cell, composition use and kit

composition, bacterium or preparation thereof, method for detecting the presence of an a / e pathogen in a sample, method for eliciting an immune response against an a / e pathogen or a component thereof in an animal, method for reducing colonization of a / e pathogen in an animal, method for reducing the spread of an a / e pathogen in an animal, method for treating or preventing infection by an a / e pathogen, method for attenuating virulence of a / e pathogen, method for selecting a compound that mitigates the virulence of a pathogen and a / e, method for producing an a / e pathogen polypeptide, recombinant polypeptide, isolated nucleic acid molecule , vector, host cell, composition use and kit

机译：组合物，细菌或其制备物，用于检测样品中a / e病原体的存在的方法，在动物中引发针对a / e病原体或其成分的免疫应答的方法，用于减少a / e定植的方法动物中的病原体，减少动物中a / e病原体传播的方法，a / e病原体治疗或预防a / e病原体感染的方法，减毒a / e病原体的毒性方法，选择减轻病原体和a / e的毒力，生产a / e病原体多肽的方法，重组多肽，分离的核酸分子，载体，宿主细胞，组合物用途和试剂盒

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摘要

"COMPOSITION, BACTERIA OR PREPARATION THEREOF, METHOD TO DETECT THE PRESENCE OF A / E PATHOGEN IN A SAMPLE, METHOD TO CAUSE AN IMMUNOLOGICAL RESPONSE AGAINST A COMPONENT OF A / AND REDUCING COLONIZATION OF A / E PATHOGEN IN AN ANIMAL, METHOD TO REDUCE DISSEMINATION OF A / E PATHHOGEN, METHOD FOR TREATMENT OR PREVENTION OF A / E PATHOGEN PATHOGEN INFECTION VIRULENCE OF A / E PATHOGEN, METHOD FOR SELECTION OF A COMPOUND THAT ATTENDS THE VIRULENCE OF AN A / E PATHOGEN ISOLATED, VECTOR, HOST CELL, COMPOSITION USE AND KIT ". The invention relates in part to secreted proteins of bacterial pathogens and methods for their use. More specifically, the invention features, in part, several novel secreted proteins common to A / E pathogens. In some embodiments of the invention, such polypeptides and nucleic acid molecules encoding such polypeptides, or parts thereof, are useful as vaccines, diagnostics, or drug selection tools for pathogenic A / E infections, or as reagents.

机译：“组成，细菌或其制备方法，用于检测样品中A / E病原体的存在的方法，对A /组分造成免疫反应的方法，以及减少动物中A / E病原体的定殖的方法，以减少传播/ E病原菌的治疗，预防或预防A / E病原菌感染的方法A / E病原菌的感染力，选择与A / E病原菌分离的毒力的化合物的方法，矢量，寄主细胞，成分使用和套件”。本发明部分涉及细菌病原体的分泌蛋白及其使用方法。更具体地说，本发明部分地具有A / E病原体共有的几种新颖的分泌蛋白。在本发明的一些实施方案中，此类多肽和编码此类多肽或其部分的核酸分子可用作用于病原性A / E感染的疫苗，诊断剂或药物选择工具，或用作试剂。

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公开/公告号BRPI0415816A

专利类型
公开/公告日2006-12-26

原文格式PDF
申请/专利权人 THE UNIVERSITY OF BRITISH COLUMBIA;UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO;
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申请/专利号BR2004PI15816
发明设计人 BRETT FINLAY;SAMANTHA GRUENHEID;WANYIN DENG;BRUCE VALLANCE;JOSE L. PUENTE;
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申请日2004-10-29
分类号C12N15/31;A61K38/16;A61K39/108;A61K35/74;C12N1/20;C12Q1/68;G01N33/569;C07K14/24;A61K39/02;A61P31/00;
国家 BR
入库时间 2022-08-21 20:59:31

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