首页> 外国专利> cell, vector, method for producing gamma carboxylated protein, isolated gamma carboxylated protein, use thereof, method for producing a pharmaceutical composition, pharmaceutical composition, method for producing gamma carboxylated human factor x, use of isolated factor x, method to produce gamma carboxylated human prothrombin, use of isolated prothrombin, and method for promoting increased or decreased coagulation in an individual

cell, vector, method for producing gamma carboxylated protein, isolated gamma carboxylated protein, use thereof, method for producing a pharmaceutical composition, pharmaceutical composition, method for producing gamma carboxylated human factor x, use of isolated factor x, method to produce gamma carboxylated human prothrombin, use of isolated prothrombin, and method for promoting increased or decreased coagulation in an individual

机译：细胞，载体，γ-羧化蛋白的制备方法，分离的γ-羧化蛋白，其用途，药物组合物的制备方法，药物组合物，γ-羧化人因子x的制备方法，x因子的分离，γ-羧化人因子的制备凝血酶原，分离的凝血酶原的用途以及促进个体凝血增加或减少的方法

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摘要

"CELL, VECTOR, PAPA METHOD TO PRODUCE GAMACARBOXILE PROTEIN, ISOLATED GAMMA-CARBOXILED PROTEIN, USE OF THE SAME, METHOD TO PRODUCE A PHARMACEUTICAL COMPOSITION FOR FARMACOUS CARDOX PHARMACEUTICAL COMPOSITION PRODUCE HUMAN CARBONXY HUMAN PROTROMBINE, USE OF ISOLATED PROTROMBINE, AND METHOD FOR PROMOTING INCREASED OR MINIMUM COAGULATION IN AN INDIVIDUAL ". The present invention relates to methods and tools for producing large amounts of gamma carboxylated protein comprising: (i) culturing a cell adapted to express a protein that requires gamma carboxylation and sym glutamyl carboxylase in a ratio of at least 10: 1 under conditions suitable for the expression of both proteins; and (ii) isolating the gamma carboxylated protein.

机译：“细胞，矢量，PAPA方法生产γ-氨基丁酸蛋白质，分离的γ-羧甲基蛋白质，使用相同的方法，生产药物成分的方法以生产羧甲基纤维素，药物成分，人参，蛋白质的方法及使用的方法或个人中的最少凝结。”。本发明涉及产生大量γ-羧化蛋白的方法和工具，其包括：（i）在条件下培养适于表达需要至少以10∶1的比率进行γ-羧化和谷氨酰羧化酶的蛋白的细胞。适用于两种蛋白质的表达; （ii）分离γ羧化蛋白。

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公开/公告号BRPI0415277A

专利类型
公开/公告日2006-12-19

原文格式PDF
申请/专利权人 ASTRAZENECA AB;
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申请/专利号BR2004PI15277
发明设计人 CHRISTEL FENGE;ANN LOEVGREN;ANDRERS THELIN;
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申请日2004-10-12
分类号C12N9/64;
国家 BR
入库时间 2022-08-21 20:59:31

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