• 主题
高级搜索  >
历史搜索 清空历史
首页> 外国专利> Tetrahidropiridin - 4 - il - indoles with a combination of Affinity to dopamine D2 Receptors and serotonin reuptake sites, a method for their preparation, Pharmaceutical compositions containing them and their use as Medicament for the treatment of CNS diseases

Tetrahidropiridin - 4 - il - indoles with a combination of Affinity to dopamine D2 Receptors and serotonin reuptake sites, a method for their preparation, Pharmaceutical compositions containing them and their use as Medicament for the treatment of CNS diseases

机译：具有与多巴胺D2受体亲和力和5-羟色胺再摄取位点亲和力结合的四氢吲哚-4--吲哚

页面导航
  • 摘要
  • 著录项
  • 相似文献

摘要

Products with dual effects from tetrahydropyridine-4-indo-peptide derivatives: inhibition of reabsorption of serum and affinity for dopamine-D2 receptor, preparation methods of these compounds, and intermediates useful for synthesis of tetrahydropyridine-4-il-indodopamine. I use this compound to make a good medicine. 1. Derivative from tetrahydropyridine-4-il-indole formula (1);e. There are also three-dimensional isomerized ceramics, tomeros, prodogas, N-oxidation, pharmaceutically acceptable salts, hydrates and solutions, including: R1 is hydrogen, halogenated, c1-3 or alcox c1-3, CN or CF3; R2 is hydrogen gene or c1-3 tar; R3 is hydrogen gene or c1-3 tar; Z is hydrogen gene or c1-3 tar; A / is a c1-3 hydrocarbon or hydrocarbon; or a and Z together form a saturated or (partially) unsaturated ring of 5 to 6 members, which can be replaced by halogenated, c1-3 hydrocarbon or phenyl, where Z refers to carbon, sulfur or nitrogen. Requirement 5: method of preparation of compound according to requirement 1,The characteristic is a compound containing a formula (2),It reacts under basic conditions to compounds containing the formula (3),I am a so-called "discrete group" with the meaning given by the symbol of formula in labor declaration No.1
机译：具有四氢吡啶-4-吲哚肽衍生物的双重作用的产品：抑制血清的重吸收和对多巴胺-D2受体的亲和力，这些化合物的制备方法以及可用于合成四氢吡啶-4-il-吲哚巴胺的中间体。我用这种化合物做一个好药。 1.衍生自式（1）的四氢吡啶-4-基吲哚的化合物; e。还存在三维异构化的陶瓷，tomeros，prodogas，N-氧化，可药用盐，水合物和溶液，包括：R1为氢，卤代，c1-3或alcox c1-3，CN或CF3; R2是氢基因或c1-3焦油; R3是氢基因或c1-3焦油; Z是氢基因或c1-3焦油; A是c1-3烃或烃;或a和Z一起形成5至6元的饱和或（部分）不饱和环，其可以被卤代的c 1-3烃或苯基取代，其中Z是指碳，硫或氮。要求5：根据要求1的化合物的制备方法，其特征是含有式（2）的化合物，它在碱性条件下与含有式（3）的化合物反应，我是所谓的“离散基团”， 1号劳工声明中公式符号所赋予的含义

著录项

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号