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Synthesis and antimalarial activity of pyrrolo3,2-fquinazoline-1,3-diamine derivatives

机译：吡咯并[3,2-f]喹唑啉-1,3-二胺衍生物的合成及抗疟活性

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摘要

The invention relates to derivatives of pyrroloquinazolinediamine, more specifically derivatives of 7-(substituted)-7H-pyrrolo[3,2-F] quinazoline-1,3-diamines that are non-toxic and are also effective in the treatment of malaria, including P. falciparum and P. vivax strains. The derivatives are certain carbamate derivatives, succinimide derivatives, alkylcarboxamides derivatives and acetamide derivative, phthalimides, alkylamines and all other amide and imide derivatives and their 1-hydroxy analogs. The derivatives of the present invention are also soluble in common organic solvents to facilitate the purification in a large scale synthesis of the composition.

机译：本发明涉及吡咯并喹唑啉二胺的衍生物，更具体地讲，是无毒的并且还有效治疗疟疾的7-（取代的）-7H-吡咯并[3,2-F]喹唑啉-1,3-二胺的衍生物，包括 P。恶心和 P。 vivax 菌株。衍生物是某些氨基甲酸酯衍生物，琥珀酰亚胺衍生物，烷基羧酰胺衍生物和乙酰胺衍生物，邻苯二甲酰亚胺，烷基胺和所有其他酰胺和酰亚胺衍生物及其1-羟基类似物。本发明的衍生物也可溶于普通的有机溶剂中以促进组合物的大规模合成中的纯化。 展开▼

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公开/公告号US7253177B2

专利类型

公开/公告日2007-08-07

原文格式PDF

申请/专利权人 AI J. LIN;JIAN GUAN;QUAN ZHANG;DONALD R. SKILLMAN;
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申请/专利号US20040971846

发明设计人 QUAN ZHANG;AI J. LIN;DONALD R. SKILLMAN;JIAN GUAN;
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申请日2004-10-22

分类号A01N43/54;A61K31/505;C07D239/00;C07D471/00;C07D487/00;C07D491/00;

国家 US

入库时间 2022-08-21 21:00:42

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