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Sdr proteins from staphylococcus capitis and their use in preventing and treating infections

机译：金黄色葡萄球菌的Sdr蛋白及其在预防和治疗感染中的用途

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摘要

An isolated and/or purified Sdr surface protein from S. capitis and nucleic acids encoding them are provided which includes the SdrX protein which possesses collagen binding activites and the SdrZL protein which possesses SdrZ-like properties. The Sdr surface proteins from S. capitis can be used in pharmaceutical compositions to treat and prevent S. capitis infectionm and can also be used in vaccines and to raise antibodies which can treat or prevent such infections. Because the SdrX protein has been shown to have collagen binding abilities, antibodies to SdrX will have the ability to inhibit or prevent the ability of S. capitis to bind to collagen.

机译：来自Is的分离和/或纯化的Sdr表面蛋白。提供了帽炎及其编码的核酸，包括具有胶原结合活性的SdrX蛋白和具有SdrZ样特性的SdrZL蛋白。来自 S的Sdr表面蛋白。帽炎可用于药物组合物中，以治疗和预防 S。头炎感染，也可用于疫苗中并产生可治疗或预防此类感染的抗体。因为已经显示SdrX蛋白具有胶原蛋白结合能力，所以针对SdrX的抗体将具有抑制或预防IS能力的能力。帽炎与胶原蛋白结合。 展开▼

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公开/公告号US2007026011A1

专利类型

公开/公告日2007-02-01

原文格式PDF

申请/专利权人 YULE LIU;JOHN VERNACHIO;JOSEPH PATTI;
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申请/专利号US20040558479

发明设计人 JOHN VERNACHIO;JOSEPH PATTI;YULE LIU;
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申请日2004-06-01

分类号A61K39/085;C07H21/04;C12N15/74;C12N1/21;C07K14/31;

国家 US

入库时间 2022-08-21 21:03:05

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