首页> 外国专利> PERIPHERAL NERVOUS SYSTEM-SPECIFIC SODIUM CHANNEL, DNA ENCODING THE SAME, CRYSTALLIZATION, X-RAY DIFFRACTION, COMPUTER MOLECULAR MODELING, RATIONAL DRUG DESIGN, MEDICINE SCREENING, AND METHOD FOR PRODUCING MEDICINE AND METHOD FOR USING THE MEDICINE

PERIPHERAL NERVOUS SYSTEM-SPECIFIC SODIUM CHANNEL, DNA ENCODING THE SAME, CRYSTALLIZATION, X-RAY DIFFRACTION, COMPUTER MOLECULAR MODELING, RATIONAL DRUG DESIGN, MEDICINE SCREENING, AND METHOD FOR PRODUCING MEDICINE AND METHOD FOR USING THE MEDICINE

机译：周围神经系统特定的钠通道，相同的DNA编码，结晶，X射线衍射，计算机分子建模，合理的药物设计，药物筛选以及药物的制备方法和药物的使用方法

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摘要

PPROBLEM TO BE SOLVED: To provide diagnosis and/or treatment of disease condition related to impaired PNS neurotransmission. PSOLUTION: The present invention provides cloning, expression, viral and delivery vectors and hosts which contain nucleic acid coding for at least one peripheral nervous system (PNS)-specific sodium channel peptide (SCP), isolated PNSSCP, and compounds and compositions and methods for isolating, crystallizing, x-ray analyzing molecular modeling, rational drug designing, selecting, making and using therapeutic or diagnostic agents or ligands having at least one peripheral nervous system (PNS)-specific sodium channel (SC)-modulating activity. PCOPYRIGHT: (C)2007,JPO&INPIT

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要解决的问题：提供与PNS神经传递受损有关的疾病状况的诊断和/或治疗。解决方案：本发明提供了克隆，表达，病毒和递送载体和宿主，其包含编码至少一种外周神经系统（PNS）特异性钠通道肽（SCP），分离的PNSSCP以及化合物和组合物的核酸分离，结晶，X射线分析分子模型，合理药物设计，选择，制备和使用具有至少一种外周神经系统（PNS）特异性钠通道（SC）调节活性的治疗剂或诊断剂或配体的方法。

版权：（C）2007，日本特许厅＆INPIT 展开▼

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公开/公告号JP2007169286A

专利类型
公开/公告日2007-07-05

原文格式PDF
申请/专利权人 ALLELIX NEUROSCIENCE INC;RESEARCH FOUNDATION OF STATE UNIV OF NEWYORK;
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申请/专利号JP20060356815
发明设计人 MANDEL GAIL;HALEGOUA SIMON;BORDEN LAURENCE A;
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申请日2006-12-29
分类号C07K14/47;C12N15/09;A61K48;A61K38;A61K31/7088;A61K45;A61P25/04;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12Q1/68;C07K16/18;
国家 JP
入库时间 2022-08-21 21:12:19

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