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the vaskularen endothelen growth factor related protein from orf virus nz10 binds and activates the mammalian vegf receptor 2

机译：orf病毒nz10的血管新生血管内皮生长因子相关蛋白结合并激活哺乳动物vegf受体2

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摘要

The invention is based on the discovery that a viral VEGF-like protein from the orf virus strain NZ2 and from the orf virus strain NZ10 is capable of binding to the extracellular domain of the VEGF receptor-2 to form bioactive complexes which mediate useful cellular responses and/or antagonize undesired biological activities. Disclosed are methods which stimulate or inhibit these biological activities, methods for therapeutic applications and antagonists of ORFV2-VEGF and/or NZ10.

机译：本发明基于以下发现：来自orf病毒株NZ2和来自orf病毒株NZ10的病毒VEGF样蛋白能够与VEGF受体2的胞外域结合以形成介导有用细胞应答的生物活性复合物。和/或拮抗不希望的生物活性。公开了刺激或抑制这些生物学活性的方法，用于治疗应用的方法以及ORFV2-VEGF和/或NZ10的拮抗剂。

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公开/公告号DE69931178D1

专利类型
公开/公告日2006-06-08

原文格式PDF
申请/专利权人 LUDWIG INSTITUTE FOR CANCER RESEARCH;UNIVERSITY OF OTAGO DUNEDIN;
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申请/专利号DE1999631178T
发明设计人 WISE LYN M.;MERCER ANDREW A.;SAVORY LOREEN J.;FLEMING STEPHEN B.;STACKER STEVEN A.;
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申请日1999-11-02
分类号A61K38;G01N33/50;A61K31/727;A61K45;A61P9;A61P17;C07H21/04;C07K14/065;C07K16/08;C07K17;C12N1/21;C12N5;C12N5/071;C12N5/10;C12N15/09;C12P21/02;C12P21/06;C12Q1/68;G01N33/15;
国家 DE
入库时间 2022-08-21 21:17:44

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