首页> 外国专利> RECOMBINANT DNA MOLECULE ENCODING OF MODIFIED SWINE FACTOR VIII (POL1212), EXPRESSION VECTORS, MODIFIED SWINE FACTOR VIII, THERAPEUTIC COMPOSITION, METHODS FOR PRODUCTION OF MODIFIED SWINE FACTOR VIII PROTEIN (VARIANTS) AND CELL LINES (VARIANTS)

RECOMBINANT DNA MOLECULE ENCODING OF MODIFIED SWINE FACTOR VIII (POL1212), EXPRESSION VECTORS, MODIFIED SWINE FACTOR VIII, THERAPEUTIC COMPOSITION, METHODS FOR PRODUCTION OF MODIFIED SWINE FACTOR VIII PROTEIN (VARIANTS) AND CELL LINES (VARIANTS)

机译：修饰的猪因子VIII（POL1212），表达载体，修饰的猪因子VIII，治疗性成分，修饰的猪因子VIII蛋白质（变体）的生产方法和细胞系（变体）的重组DNA分子编码

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FIELD: biotechnology, in particular production of modified swine factor VIII (POL1212).;SUBSTANCE: DNA molecule encoding of modified swine factor VIII is cloned in expression vector, having functionality in mammalian cells. Modified swine factor VIII protein is obtained by cultivation of mammalian cell line BHK CRL-1632 (ATCC), BHK 1632, or CHO-K1, transfected with vector. Therapeutic composition for treatment of subjects suffering from deficit of factor VIII, such as haemophilia, contains effective amount of swine factor VIII protein.;EFFECT: effective agent for treatment of factor VIII deficit.;13 cl, 8 dwg, 7 ex

机译：领域：生物技术，特别是修饰的猪因子VIII（POL1212）的生产。;物质：编码修饰的猪因子VIII的DNA分子被克隆到表达载体中，在哺乳动物细胞中具有功能。通过培养用载体转染的哺乳动物细胞系BHK CRL-1632（ATCC），BHK 1632或CHO-K1获得修饰的猪因子VIII蛋白。用于治疗患有凝血因子VIII缺乏症（如血友病）的受试者的治疗组合物包含有效量的猪凝血因子VIII蛋白;效果：治疗凝血因子VIII缺乏症的有效药物; 13 cl，8 dwg，7 ex

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公开/公告号RU2285724C2

专利类型
公开/公告日2006-10-20

原文格式PDF
申请/专利权人 EHMORI JUNIVERSITI;
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申请/专利号RU20020124123
发明设计人 LOLLAR DZHON S. (US);
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申请日2001-02-16
分类号C12N15/12;C12N15/63;C12N5/10;C07K14/755;C12P21;
国家 RU
入库时间 2022-08-21 21:21:26

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