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NEW APPLICATION OF COMBINED SELECTIVE ANTAGONISTS OF DOPAMINE D2 RECEPTOR AND AGONISTS OF 5-НТ _1A RECEPTOR

机译：多巴胺D2受体组合选择性拮抗剂和5-НТ_{1A 受体激动剂的新应用}

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FIELD: veterinary medicine and veterinary pharmacology.;SUBSTANCE: invention relates to application of compounds combining properties of selective antagonists of dopamine D2 receptor and agonists of 5-HT_1A receptor, in particular (R)-(-)-2-[5-(4-fluorophenyl)-3-piridylmethylaminomethyl]-chromane or pharmaceutically acceptable salts thereof, or N-(4'-fluoro-3-biphenylmethyl)-N-2-(3-cyanophenoxyethyl)-amine or pharmaceutically acceptable salts thereof. Said compounds are useful in veterinary medicine for treatment of self-directed traumatic disorders, associated with behavioral stress-factors, and/or compulsive disorders, associated with behavioral stress-factors, and/or anxiety, associated with behavioral stress-factors.;EFFECT: effective method for treatment and prophylaxis of disorders, associated with behavioral stress-factors.;6 cl, 3 ex

机译：发明领域本发明涉及结合多巴胺D 2受体的选择性拮抗剂和5-HT _{1A 受体激动剂，特别是（R）-（-）的化合物的应用。）-2- [5-（4-氟苯基）-3-吡啶基甲基氨基甲基]-苯并二氢吡喃或其可药用盐，或N-（4'-氟-3-联苯甲基）-N-2-（3-氰基苯氧基乙基）-胺或其药学上可接受的盐。所述化合物在兽医学中可用于治疗与行为应激因素有关的自发性创伤性疾病和/或与行为应激因素有关的强迫性疾病和/或与行为应激因素有关的焦虑症。：治疗和预防与行为压力因素相关的疾病的有效方法。; 6 cl，3 ex}

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公开/公告号RU2283648C2

专利类型
公开/公告日2006-09-20

原文格式PDF
申请/专利权人 MERK PATENT GMBKH;
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申请/专利号RU20030115433
发明设计人 BARTOSHIK GERD (DE);
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申请日2001-10-25
分类号A61K31/4433;A61K31/275;A61P25/22;A61P25/18;A61P43;
国家 RU
入库时间 2022-08-21 21:21:30

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NEW APPLICATION OF COMBINED SELECTIVE ANTAGONISTS OF DOPAMINE D2 RECEPTOR AND AGONISTS OF 5-НТ 1A RECEPTOR

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NEW APPLICATION OF COMBINED SELECTIVE ANTAGONISTS OF DOPAMINE D2 RECEPTOR AND AGONISTS OF 5-НТ _1A RECEPTOR