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首页> 外国专利> Polynucleotides cognate antigen STEM CELLS IN PROSTATE (PSCA), and the encoded MI protein (peptide), hybridomas and transgenic animals for the production of antibody, compositions for treatment, prevention, diagnosis and prognosis CANCER BASED THEREON (VERSIONS) METHOD FOR DETERMINING OF PRESENCE IN THE SAMPLED STUDY, METHOD FOR GENERATING AN IMMUNE RESPONSE, METHOD FOR DELIVING A CYTOTOXIC OR DIAGNOSTIC AGENT TO A CELL, METHOD FOR INHIBITING CANCER CELL GROWTH FROM THEIR USE

Polynucleotides cognate antigen STEM CELLS IN PROSTATE (PSCA), and the encoded MI protein (peptide), hybridomas and transgenic animals for the production of antibody, compositions for treatment, prevention, diagnosis and prognosis CANCER BASED THEREON (VERSIONS) METHOD FOR DETERMINING OF PRESENCE IN THE SAMPLED STUDY, METHOD FOR GENERATING AN IMMUNE RESPONSE, METHOD FOR DELIVING A CYTOTOXIC OR DIAGNOSTIC AGENT TO A CELL, METHOD FOR INHIBITING CANCER CELL GROWTH FROM THEIR USE

机译：多核苷酸同源抗原STEM细胞（PSCA），编码的MI蛋白（肽），杂交瘤和转基因动物用于生产抗体，治疗，预防，诊断和预后的组合物基于癌症的癌症（版本）测定存在的方法在抽样研究中，产生免疫反应的方法，将细胞毒性或诊断性试剂分配给细胞的方法，从其使用中抑制癌细胞生长的方法

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摘要

PSCA and its encoded protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, propylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.
机译：描述了PSCA及其编码的蛋白及其变体，其中PSCA在正常成人组织中表现出组织特异性表达，并在表I所列的癌症中异常表达。因此，PSCA提供了诊断，预后，丙基和/或治疗靶标对于癌症。 PSCA基因或其片段，或其编码的蛋白质，或其变体，或其片段，可用于引发体液或细胞免疫应答。与PSCA反应的抗体或T细胞可用于主动或被动免疫。

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