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NOVEL HEMOGLOBIN SCAVENGER RECEPTOR, CD163, AND METHOD OF INCREASING CD163 EXPRESSION ON HUMAN STEM CELLS AND STIMULATION OF ERYTHROID PROGENITORS
NOVEL HEMOGLOBIN SCAVENGER RECEPTOR, CD163, AND METHOD OF INCREASING CD163 EXPRESSION ON HUMAN STEM CELLS AND STIMULATION OF ERYTHROID PROGENITORS
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机译：新型血红蛋白清除剂受体CD163以及增加CD163在人干细胞中表达和刺激类红血球祖细胞的方法
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摘要
A novel CD163 hemoglobin scavenger receptor is described. Methods and compositions for stimulating the growth, proliferation, differentiation and/or mobilization of stem and/or progenitor cells are also described. The method involves administering an effective amount of a substance which can activate the CD163 hemoglobin scavenger receptor signal transduction pathway. The methods can be used in cell culture, to obtain a source of CD163 receptor containing cells, assays, assays for identifying CD163 receptor ligands or modulators. The methods and compositions are useful in stimulating hematopoiesis and in treating a wide range of conditions including cytopenias, anemias and for use in preparing cells for transplantation.
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