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COMPOSITIONS AND METHODS FOR REGULATING THYROID HORMONE METABOLISM AND CHOLESTEROL AND LIPID METABOLISM VIA THE NUCLEAR RECEPTOR CAR

机译：通过核受体车调节甲状腺激素代谢和胆固醇和脂质代谢的组合物和方法

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摘要

Methods for identifying agents which alter thyroid hormone metabolism or cholesterol and lipid metabolism by modulating expression and/or activity of the nuclear receptor CAR are provided. Also provided are compositions containing such agents and methods of using such agents to alter thyroid hormone metabolism or cholesterol and lipid metabolism in a subject. Administration of such agents is useful in the treatment of conditions such as obesity, cholesterolemia and dyslipidemia.

机译：提供了鉴定通过调节核受体CAR的表达和/或活性来改变甲状腺激素代谢或胆固醇和脂质代谢的药物的方法。还提供了包含此类试剂的组合物以及使用此类试剂改变受试者的甲状腺激素代谢或胆固醇和脂质代谢的方法。此类试剂的给药可用于治疗肥胖症，胆固醇血症和血脂异常。

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公开/公告号EP1490084A4

专利类型
公开/公告日2006-06-07

原文格式PDF
申请/专利权人 SMITHKLINE BEECHAM CORPORATION;
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申请/专利号EP20030719339
发明设计人 MAGLICH JODI MARIE;MOORE JOHN TOMLIN;
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申请日2003-02-28
分类号G01N33/68;A61K31/198;A61K38;A61K49;C07K14/705;G01N33/53;G01N33/567;G01N33/74;G01N33/78;G01N33/92;
国家 EP
入库时间 2022-08-21 21:30:06

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