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METHOD OF DIAGNOSING DISEASE CAUSED BY MORPHOLOGICAL CHANGE IN PROTEIN BY USING THE NEUTRON SCATTERING METHOD

机译：中子散射法诊断蛋白质形态变化引起的疾病

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摘要

A method of diagnosing a disease caused by a morphological change in a test protein characterized by comprising irradiating the test protein having been dissolved or dispersed in heavy water with cold neutrons and measuring the morphology of the test protein based on the scattering of the cold neutrons. According to this method, a morphological change in a protein in an aqueous solution can be observed while keeping the protein in the non-invaded and natural state and thus the relationship between the morphological change and a disease can be clarified. As a result, it becomes possible to diagnose a disease caused by the morphological change in the protein and screen a drug.

机译：诊断由测试蛋白质的形态变化引起的疾病的方法，其特征在于包括用冷中子照射已经溶解或分散在重水中的测试蛋白质，并基于冷中子的散射来测量测试蛋白质的形态。根据该方法，可以在保持蛋白质处于非侵入性和自然状态的同时观察水溶液中蛋白质的形态变化，因此可以阐明形态变化与疾病之间的关系。结果，可以诊断由蛋白质的形态变化引起的疾病并筛选药物。

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公开/公告号WO2006064819A1

专利类型
公开/公告日2006-06-22

原文格式PDF
申请/专利权人 HIGH ENERGY ACCELERATOR RESEARCH ORGANIZATION;YASUDA TORU;WADA KEIJI;AOKI SHUNSUKE;SUZUKI JUNICHI;FUJIWARA SATORU;SHIMIZU HIROHIKO;ADACHI TOMOHIRO;JUNTENDO UNIVERSITY;JAPAN AS REPRESENTED BY PRESIDENT OF NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY;RIKEN;JAPAN ATOMIC ENERGY AGENCY;NAITO SACHIO;FURUSAKA MICHIHIRO;IKEDA SUSUMU;MOCHIZUKI HIDEKI;
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申请/专利号WO2005JP22898
发明设计人 IKEDA SUSUMU;FURUSAKA MICHIHIRO;FUJIWARA SATORU;MOCHIZUKI HIDEKI;SHIMIZU HIROHIKO;ADACHI TOMOHIRO;WADA KEIJI;AOKI SHUNSUKE;NAITO SACHIO;YASUDA TORU;SUZUKI JUNICHI;
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申请日2005-12-13
分类号G01N23/206;G01N33/15;G01N33/483;G01N33/50;
国家 WO
入库时间 2022-08-21 21:30:35

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