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HEME-REGULATED EUKARYOTIC INITIATION FACTOR 2 ALPHA KINASE KNOCKOUT MICE AND METHODS FOR USE
HEME-REGULATED EUKARYOTIC INITIATION FACTOR 2 ALPHA KINASE KNOCKOUT MICE AND METHODS FOR USE
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机译:血红素调节的真核生物起始因子2α激酶敲除小鼠及其使用方法
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摘要
The targeted disruption of the gene encoding the heme-regulated eIF2-kinase (HRI) in mice establishes that HRI, which is expressed predominantly in erythroid cells, regulates the synthesis of both alpha and beta globins in red blood cell precursors by inhibiting the general translation initiation factor eIF2. HRI is a physiological regulator of gene expression in the erythroid lineage and acts both as a sensor of heme and an effector controlling the initiation of translation. Accordingly regulation of HRI can be used to control proliferation of cells, especially cells of hematopoietic origin, using compositions and compounds identified using HRI deficient mice.
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