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ACTIVITY-BASED PROBES FOR PROTEIN TYROSINE PHOSPHATASES
ACTIVITY-BASED PROBES FOR PROTEIN TYROSINE PHOSPHATASES
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机译：蛋白质酪氨酸磷酸酶的基于活动的问题
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摘要
Provided are compounds capable of covalently binding to a protein tyrosine phosphatase (PTP). The compounds comprise Formula (A): Also provided are compositions comprising one of the above compounds covalently bound to a member of the PTP superfamily, methods of labeling a PTP using the compounds, methods of isolating a PTP from a mixture of proteins using the compounds, methods of evaluating whether a substance is an inhibitor of a PTP using the compounds, methods of evaluating the specificity of an inhibitor of a PTP using the compounds, methods of identifying a PTP involved in a disease in a mammal using the compounds, and methods of diagnosing a disease in a mammal using the compounds.
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