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Powder composition, microspheres, method for forming a particulate composition comprising perforated microstructures by spray drying and method for forming powder comprising perforated microstructures by spray drying
Powder composition, microspheres, method for forming a particulate composition comprising perforated microstructures by spray drying and method for forming powder comprising perforated microstructures by spray drying
A powder composition, that comprises a plurality of perforated microstructures comprising an active agent having a mean aerodynamic diameter of less than 5 mm and a bulk density of less than 0.5 g/cm3, wherein, when suspended in a fluid medium, the volume of the medium displaced by the perforated microstructures comprises less than 70 % of the average microstructure volume defined by the microstructure boundary if the microstructures were solid. A method for forming a particulate composition comprising perforated microstructures by spray drying and a method for forming powder comprising perforated microstructures by spray drying. Obtained compositions are intended for administration of active agent to the pulmonary air passages of a patient. Particulate can be used in a dry powder form or in a stabilised dispersion form comprising non-aqueous continual stage.
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机译：一种粉末组合物，其包含多个穿孔的微结构，所述微结构包含平均空气动力学直径小于5mm，堆积密度小于0.5g / cm 3的活性剂，其中当悬浮在流体介质中时，如果微结构是固体，则由穿孔的微结构置换的介质占微结构边界所限定的平均微结构体积的不到70％。一种通过喷雾干燥形成包括多孔微结构的颗粒组合物的方法，以及通过喷雾干燥形成包括多孔微结构的粉末的方法。所获得的组合物旨在将活性剂给予患者的肺空气通道。颗粒可以以干粉形式或包括非水连续阶段的稳定分散体形式使用。
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