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Developments in biologically active methylene blue derivatives(2)

机译:具有生物活性的亚甲基蓝衍生物的研究进展(2)

摘要

A phenothiazinium compound of Formula (I) for use as an antimicrobial agent for the prevention of microbial infections wherein: Rl, R2, R3 and R4 each independently is an optionally substituted linear, branched or cyclic hydrocarbon group;or Rl and R2 or R3 and R4 together with the N atom to which they are attached form an optionally substituted 5-, 6- or 7- membered ring; XP- is a counteranion; and P is 1, 2 or 3. The invention also relates to compositions comprising phenothiazinium. compounds, to selected compounds and their use as medicaments, as PDT agents, as photodiagnostic agents, to a conjugate or composite formed between a phenothiazinium. and a polymer; and to a method for sterilising fluids in which the fluid is passed over the conjugate or composite whilst it is illuminated. The compounds are biologically active photosensitisers which are strongly photocytotoxic and have application in the areas of photodynamic therapy (PDT), as well as for the diagnosis and detection of medical conditions and related uses in photochemical internalisation, in the production of cancer vaccines, in the treatment and prevention of microbial infections and in photodisinfection or photosterilisation.
机译:用作预防微生物感染的抗微生物剂的式(I)的吩噻嗪鎓化合物,其中:R1,R2,R3和R4各自独立地是任选取代的直链,支链或环状烃基;或R1和R2或R3和R4与它们所连接的N原子一起形成任选取代的5-,6-或7-元环; X 为抗衡阴离子; P为1、2或3。本发明还涉及包含吩噻嗪鎓的组合物。化合物,选择的化合物及其作为药物,作为PDT试剂,作为光诊断剂的用途,与在吩噻嗪鎓之间形成的结合物或复合物。和聚合物;本发明还涉及一种对流体进行消毒的方法,其中,在照明时使流体流过结合物或复合物。该化合物是具有强烈光细胞毒性的生物活性光敏剂,可用于光动力疗法(PDT)领域,以及诊断和检测医学状况以及在光化学内在化,癌症疫苗生产中的相关用途,治疗和预防微生物感染以及光消毒或光消毒。

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