首页> 外国专利> DERIVATIVES OF BENZOSULPHONILYAMINOPYRIDIN-2-EFFLES AND RELATED COMPOUNDS AS 11-BETA-HYDROXYSTEROID-DEGYDROGENASE 1 TYPE (11-BETA-HSD-1) INHIBITORS FOR TREATMENT OF DIABETES FOR TREATMENT OF DIABETES TYPE 1 (11-BETA-HSD-1) FOR DIABETES TREATMENT

DERIVATIVES OF BENZOSULPHONILYAMINOPYRIDIN-2-EFFLES AND RELATED COMPOUNDS AS 11-BETA-HYDROXYSTEROID-DEGYDROGENASE 1 TYPE (11-BETA-HSD-1) INHIBITORS FOR TREATMENT OF DIABETES FOR TREATMENT OF DIABETES TYPE 1 (11-BETA-HSD-1) FOR DIABETES TREATMENT

机译：苯磺酰亚氨基吡啶-2-酮的衍生物和相关化合物，作为治疗糖尿病的11-BETA-羟基甾体-脱氢酶1型（11-BETA-HSD-1）抑制剂，用于治疗1型糖尿病（11-BETA）糖尿病治疗

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摘要

This invention relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof, formula (I), wherein R is selected from the group consisting of (CC) alkyl, - (CRR) (C — C) cycloalkyl, - (CRR) (CC) aryl and - (CRR) (4-10) membered heterocyclyl; b and k are each independently selected from 1 and 2; J is selected from the group consisting of 0, 1, and 2; t, u, p, q, and v are each independently selected from the group consisting of 0, 1, 2, 3, 4, and 5; T is a (6-10) membered heterocyclyl containing at least one nitrogen atom; R is selected from the group consisting of H, (C — C) alkyl, - (CRR) (C — C) cycloalkyl, - (CRR) (C — C) aryl, and - (CRR) (4-10) membered heterocyclyl; each R and R are independently selected from H and (C — C) alkyl, carbon atoms of groups T, R, R, R and R, each optionally may be substituted with 1-5 groups of R; R are defined in the claims. The compounds of this invention are inhibitors of 11-β-hsd-1 and are believed to be useful for the treatment of diabetes, obesity, glaucoma, osteoporosis, cognitive disorders, immune disorders, depression, arterial hypertension and metabolic diseases.

机译：本发明涉及式（I）的化合物或其药学上可接受的盐，式（I），其中R选自：（CC）烷基，-（CRR）（CC）环烷基，-（CRR）。）（CC）芳基和-（CRR）（4-10）元杂环基; b和k各自独立地选自1和2; J选自0、1和2; t，u，p，q和v各自独立地选自0、1、2、3、4和5; T是含有至少一个氮原子的（6-10）元杂环基; R选自由以下各项组成的组：H，（CC）烷基，-（CRR）（CC）环烷基，-（CRR）（CC）芳基和-（CRR）（4-10）元杂环基每个R和R独立地选自H和（CC）烷基，基团T，R，R，R 1和R 2的碳原子，每个可任选地被1-5个R基团取代; R在权利要求中定义。本发明的化合物是11-β-hsd-1的抑制剂，被认为可用于治疗糖尿病，肥胖，青光眼，骨质疏松，认知障碍，免疫障碍，抑郁症，动脉高血压和代谢性疾病。

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公开/公告号EA200600990A1

专利类型
公开/公告日2006-10-27

原文格式PDF
申请/专利权人 ПФАЙЗЕР ИНК.;
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申请/专利号EA20060000990
发明设计人 ЭДВАРДС МАРТИН ПОЛ;ДЖОНСОН ТЕОДОР ОТТО МЛ.;НАИР САДЖИВ КРИШНАН;СИУ МАЙКЛ;ТЭЙЛОР УЭНДИ ДАЙАНН;КРИППС СТЕФАН ДЖЕЙМС;ВАН ЮН;ЧЭН ХЭНМЯО;СМИТ КРИСТОФЕР РОНАЛЬД;
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申请日2004-12-06
分类号A61K31/44;A61K31/4436;A61K31/4545;A61P3/04;A61P3/10;C07C311/36;C07C311/37;C07D209/08;C07D213/02;C07D213/76;C07D215/38;C07D235/06;C07D239/42;C07D401/12;C07D401/14;C07D405/12;C07D409/12;C07D417/12;C07D471/04;C07D487/04;C07D491/04;C07D513/04;
国家 EA
入库时间 2022-08-21 21:39:39

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