首页> 外国专利> BRANCHED CHAIN AMINO ACID-DEPENDENT AMINOTRANSFERASE INHIBITORS AND THEIR USE IN THE TREATMENT OF DIABETIC RETINOPATHY

BRANCHED CHAIN AMINO ACID-DEPENDENT AMINOTRANSFERASE INHIBITORS AND THEIR USE IN THE TREATMENT OF DIABETIC RETINOPATHY

机译：支链氨基酸依赖性氨基酸转移酶抑制剂及其在糖尿病视网膜病变治疗中的应用

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摘要

The present invention is directed to a method for the prophylactic and therapeutic treatment of diabetic retinopathy. The method involves the administration of an inhibitor of formulae (I), (II) and (III) of the branch chain amino acid-dependent aminotransferase (BCAT) pathway to an animal, such as a mammal, in particular a human, in an amount sufficient to treat the retina for diabetic retinopathy prophylactically or therapeutically. The present invention is also directed to several novel inhibitors of formula (IV) of the BCAT pathway. In formulae (I-IV), n, m, X and R1-R13 have the meanings given in the description.

机译：本发明涉及糖尿病性视网膜病的预防和治疗方法。该方法包括将支链氨基酸依赖性转氨酶（BCAT）途径的式（I），（II）和（III）的抑制剂给予动物，例如哺乳动物，特别是人。足以预防或治疗视网膜的糖尿病视网膜病变的量。本发明还涉及BCAT途径的几种新型式（IV）抑制剂。在式（I-IV）中，n，m，X和R 1 -R 13具有说明书中给出的含义。

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公开/公告号EA006597B1

专利类型
公开/公告日2006-02-24

原文格式PDF
申请/专利权人 WARNER-LAMBERT COMPANY;THE PENN STATE RESEARCH FOUNDATION;WAKE FOREST UNIVERSITY;
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申请/专利号EA20010000791
发明设计人 BRYANS JUSTIN STEPHEN;HU LAIN-YEN;HUTSON SUSAN M.;LANQUE KATHRYN FOLEY;LIETH ERICH;RAFFERTY MICHAEL FRANCIS;RYDER TODD ROBERT;SU TI-ZHI;WELTY DEVIN FRANKLIN;WUSTROW DAVID JUERGEN;
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申请日2000-11-08
分类号A61P1/04;C07C229/28;A61K31/19;A61K31/194;A61K31/195;A61K31/27;A61P3/10;A61P9/10;A61P25;A61P25/08;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P27/02;A61P27/06;A61P29;A61P43;C07C55/28;C07C59/11;C07C59/62;C07C229/10;C07C229/14;C07C229/18;C07C229/22;C07C229/34;C07C233/08;C07C233/47;C07C271/22;
国家 EA
入库时间 2022-08-21 21:39:39

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