首页> 外国专利> recombinant microbial host cell, nucleic acid construct, method for producing an enzyme and / or antimicrobial agent, fusion product, additive and animal feed composition, transgenic non-human animal or products or elements thereof, uses of the fusion product, the co-expression of an antimicrobial agent and an enzyme, and a protective peptide, and, method for identifying a protective peptide

recombinant microbial host cell, nucleic acid construct, method for producing an enzyme and / or antimicrobial agent, fusion product, additive and animal feed composition, transgenic non-human animal or products or elements thereof, uses of the fusion product, the co-expression of an antimicrobial agent and an enzyme, and a protective peptide, and, method for identifying a protective peptide

机译：重组微生物宿主细胞，核酸构建体，酶和/或抗微生物剂的生产方法，融合产物，添加剂和动物饲料组合物，转基因非人类动物或其产物或元件，融合产物的用途，共表达剂和酶，保护肽的制备，以及鉴定保护肽的方法

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摘要

"RECOMBINANT MICROBIAN HOST CELL, NUCLEIC ACID CONSTRUCTION, METHOD FOR PRODUCING AN ANTIMICROBIAN ENZYME AND / OR AGENT, FUSION PRODUCT, ADDITIVE AND COMPOSITION OF ANIMAL HUMAN OR PRODUCT UNUSE PRODUCTS CO-EXPRESSION OF AN ANTIMICROBIAN AGENT AND AN ENZYME, AND A PROTECTIVE PEPTIDE, AND METHOD FOR IDENTIFYING A PROTECTIVE PEPTIDE ". The invention relates to the use of co-expression of an antimicrobial agent and an enzyme in order to improve yield and / or economy of total production. Examples of antimicrobial agents are antimicrobial peptides such as lactoferricins and antimicrobial enzymes such as lysozyme and glucose oxidase and examples of enzymes are endoglucanase, xylanase, phytase, protease, galactanase, mananase, dextranase, alpha-galactosidase, pectate lyase, pectate lyase. amylase and glycoamylase. A fusion product comprising the antimicrobial agent and enzyme and a cleavable linker is novel and can be used in animal feed and feed additives. The invention also describes the use of a protection domain wherein at least 50% of the amino acid residues comprised in the peptide protection domain are D (Asp) and / or E (Glu). The protective or extinction domain serves to temporarily and reversibly inactivate the antimicrobial peptide during expression.

机译：“重组微生物寄主细胞，核酸构建，生产抗微生物酶和/或活性剂的方法，融合产物，动物人或产品的添加剂和组成，以及未使用的产品与抗微生物剂和酶共同表达的产物以及保护剂和鉴定保护性肽的方法”。本发明涉及抗表达剂和酶的共表达在提高总产量的产量和/或经济性方面的用途。抗菌剂的实例是抗菌肽，例如乳铁蛋白，以及抗菌酶，例如溶菌酶和葡萄糖氧化酶，酶的实例是内切葡聚糖酶，木聚糖酶，植酸酶，蛋白酶，半乳聚糖酶，甘露聚糖酶，葡聚糖酶，α-半乳糖苷酶，果胶酸裂合酶，果胶酸裂合酶。淀粉酶和糖化酶。包含抗微生物剂和酶以及可裂解的接头的融合产物是新颖的，可用于动物饲料和饲料添加剂。本发明还描述了保护结构域的用途，其中肽保护结构域中包含的至少50％的氨基酸残基是D（Asp）和/或E（Glu）。保护或消光结构域用于在表达过程中暂时和可逆地灭活抗菌肽。

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公开/公告号BRPI0413833A

专利类型
公开/公告日2006-10-24

原文格式PDF
申请/专利权人 NOVOZYMES A/S;
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申请/专利号BR2004PI13833
发明设计人 EJNER BECH JENSEN;HANS-HENRIK KRISTENSEN HOGENHAUG;PETER KAMP HANSEN;POUL ERIK PEDERSEN;PER HOLSE MYGIND;
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申请日2004-09-13
分类号C12N5/10;A23K1/17;C07K14/47;C12N15/62;C12N9/90;A23K1/00;C12N15/82;A01K67/027;C07K1/107;
国家 BR
入库时间 2022-08-21 21:40:01

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