Su00ecntese beta L - 2 '- deu00f3xi - nucleosu00ecdeos
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机译：SU00哦cn特色beta l - 2 '- 的U00发3喜 - 你UCL EOSU00EC的OS
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摘要
"Su00ecntese 225 - L - 2 39 - deu00f3xi - nucleosu00ecdeos".An improved process for the preparation of nucleoside 2 39 - modified and 2 39 - deu00f3xi nucleoside, such as 225 - L - 2 39 - deu00f3xi thymidine (LDT) is provided.In particular, the improved process is directed to the synthesis of a 2 39 - deu00f3xinucleosu00eddeo which can use different materials of initiation.But that goes on through the intermediary of chlorine - sugar or via an intermediary of 2,2 '- anhydro 39 1 furanosil - nucleobase.Where an intermediary base 2.2 39 anhydro 1 - furanosila is used, a reducing agent, such as red - A1, and a capture agent, such as 15 - crown - 5 - ether.That causes a substitution reaction and formation of the product intramolecular nucleoside desired in good yields are employed.An alternative process of this invention uses an intermediary base 2.2 39 anhydro - furanosila without a capture agent to provide 2 39 - deu00f3xinucleosu00eddeo in good yields.The compounds made according to the present invention can be used as intermediates in the preparation of other nucleoside analogues, or can be used directly as antiviral agents or antiNeoplastic.
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