首页> 外国专利> a method for producing an antibody to a polypeptide, antibody produced therein, antibody or antibody fragment that binds to a polypeptide, methods for reducing or inhibiting il-20 induced proliferation or differentiation of hematopoietic cells and hematopoietic cell progenitors, to reduce il-20 induced inflammation, to suppress an inflammatory response in an inflamed mammal, to treat a mammal afflicted with an inflammatory disease, to treat a pathological condition in a patient associated with il-20 activity

a method for producing an antibody to a polypeptide, antibody produced therein, antibody or antibody fragment that binds to a polypeptide, methods for reducing or inhibiting il-20 induced proliferation or differentiation of hematopoietic cells and hematopoietic cell progenitors, to reduce il-20 induced inflammation, to suppress an inflammatory response in an inflamed mammal, to treat a mammal afflicted with an inflammatory disease, to treat a pathological condition in a patient associated with il-20 activity

机译:产生针对多肽的抗体的方法,在其中产生的抗体,与多肽结合的抗体或抗体片段,减少或抑制il-20诱导的造血细胞和造血细胞祖细胞增殖或分化,减少il-20诱导的增殖的方法炎症,抑制发炎的哺乳动物的炎症反应,治疗患有炎症性疾病的哺乳动物,治疗与il-20活性相关的患者的病理状况

摘要

"METHOD FOR PRODUCING AN ANTIBODY FOR A HYPEROPHYETIC PROPELLER, ANTIBODY PRODUCED BY THE SAME, ANTIBODY OR ANTIBODY FRAGMENT, A METHOD FOR REDUCING OR INHIBITING HYDROPATHY PROHYPATHY TO REDUCE IL-20-INDUCED INFLAMMATION, TO SUPPRESS AN INFLAMMATORY RESPONSE IN AN INFLAMMED MAMMALIAN, TO TREAT A MAMMALIAN AFFILIATED WITH AN INFLAMMATORY DISEASE IN A PATIENT AFFILIABLE CONDITION. The present invention is directed to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-20 peptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. The present invention includes anti-IL-20 and anti-IL22RA antibodies and binding partners, as well as methods for antagonizing IL-20 using such antibodies and binding partners.
机译:“生产高物理性螺旋桨抗体的方法,由相同,抗体或抗体片段产生的抗体,用于减少或抑制减轻由IL-20引起的炎症的炎症反应的水肿性疾病的方法,从而减轻了炎症反应,从而减轻了炎症。在患者适合的条件下治疗患有炎症性疾病的哺乳动物本发明涉及阻断,抑制,减少,拮抗或中和IL-20肽分子的活性,IL-20和IL-22是涉及的细胞因子。本发明包括抗IL-20和抗IL22RA抗体和结合伴侣,以及使用这种抗体和结合伴侣拮抗IL-20的方法。

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