首页> 外国专利> Polypeptide, immunotherapeutic agent for the treatment of psoriasis, isolated nucleic acid sequence or complement, single-stranded and double-stranded vectors, isolated nucleic acid sequence or immunogenic variant thereof, methods for the production of polypeptides, and for treatment and clinical remission of psoriasis, and, microbial host cell

Polypeptide, immunotherapeutic agent for the treatment of psoriasis, isolated nucleic acid sequence or complement, single-stranded and double-stranded vectors, isolated nucleic acid sequence or immunogenic variant thereof, methods for the production of polypeptides, and for treatment and clinical remission of psoriasis, and, microbial host cell

机译：多肽，用于治疗牛皮癣的免疫治疗剂，分离的核酸序列或补体，单链和双链载体，分离的核酸序列或其免疫原性变体，多肽的生产方法以及牛皮癣的治疗和临床缓解和微生物宿主细胞

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"Polypeptide, immunotherapeutic agent for the treatment of psoriasis, sequencing of isolated nucleic acid or its complement, vectors of single filament, and of double filament, sequential of the nucleic acid for prostate and isolates TREATMENT AND CLINICAL REMISSION OF PSORIASIS, AND, MICROBIAN HOST CELL "Polypeptides, which comprise particulate antigen amino acid sequences, or immunogenic variants thereof, are exposed for treatment and clinical remission. of psoriasis. Also disclosed are nucleic acid sequences encoding said polypeptides, vectors incorporating such nucleic acid sequences, methods for genetically engineering microbial host cells to produce such polypeptides, and such recombinant microbial host cells. In another embodiment, immunotherapeutic agents incorporating polypeptides or nucleic acid sequences are exposed for the treatment and clinical remission of psoriasis. In another embodiment, methods for producing polypeptides using recombinant microbial host cells are exposed. Finally, methods for the treatment and clinical remission of psoriasis, comprising administering a pharmaceutical composition comprising one or more of the polypeptides or one or more of the nucleic acid sequences are exposed. Polypeptides induced a cellular THI immune response, a positive intradermal reaction, and a blastogenic response in peripheral blood lymphocytes following clinical remission of lesions. Peripheral blood lymphocyte populations, which are altered in psoriasis patients, returned to normal values in patients who received the polypeptides and experienced clinical remission of lesions after treatment.

机译：“多肽，用于治疗牛皮癣的免疫治疗剂，对分离的核酸或其补体进行测序，单丝和双丝载体，前列腺核酸的分离顺序，并分离出牛皮癣的治疗和临床缓解，以及微生物宿主将包含颗粒状抗原氨基酸序列或其免疫原性变体的CELL“多肽暴露以进行治疗和临床缓解。牛皮癣。还公开了编码所述多肽的核酸序列，掺入此类核酸序列的载体，对微生物宿主细胞进行基因工程以产生此类多肽的方法以及此类重组微生物宿主细胞。在另一个实施方案中，暴露结合了多肽或核酸序列的免疫治疗剂用于牛皮癣的治疗和临床缓解。在另一个实施方案中，暴露了使用重组微生物宿主细胞生产多肽的方法。最后，用于牛皮癣的治疗和临床缓解的方法，包括给予包含一种或多种多肽或一种或多种核酸序列的药物组合物暴露。临床缓解后，多肽在外周血淋巴细胞中诱导了细胞THI免疫反应，阳性皮内反应和成胚反应。在牛皮癣患者中改变的外周血淋巴细胞群体在接受该多肽并在治疗后经历了临床病变缓解的患者中恢复到正常值。

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公开/公告号BR0208140A

专利类型
公开/公告日2005-12-13

原文格式PDF
申请/专利权人 AKIVA LLC;
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申请/专利号BR20020208140
发明设计人 JOSE ANTONIO ODALY;
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申请日2002-03-04
分类号A61K38/00;A01N43/04;
国家 BR
入库时间 2022-08-21 21:40:21

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