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Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells
Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells
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机译：在人CD40 +细胞中表达嵌合小鼠和人CD40配体的方法
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摘要
This invention relates to genes which encode accessory molecule ligands, such as the CD40 ligand and their use for immunomodulation, vaccination and treatments of various human diseases, including malignancies and autoimmune diseases. This invention also describes the use of accessory molecule ligands which are made up of various domains and subdomain portions of molecules derived from the tumor necrosis factor family. The chimeric molecules of this invention contain unique properties which lead to the stabilization of their activities and thus greater usefulness in the treatment of diseases. Vectors for expressing genes which encode the accessory molecule ligands of this invention are also disclosed.
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