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Nucleophilic substitution reactions of difluorormethyl phenyl sulfone with alkyl halides leading to the facile synthesis of terminal 1,1-difluoro-1-alkenes and difluoromethylalkanes
Nucleophilic substitution reactions of difluorormethyl phenyl sulfone with alkyl halides leading to the facile synthesis of terminal 1,1-difluoro-1-alkenes and difluoromethylalkanes
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机译：二氟甲基苯砜与烷基卤的亲核取代反应可轻松合成末端1,1-二氟-1-烯烃和二氟甲基烷烃
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摘要
(Benzenesulfonyl)difluoromethyl anion, in situ generated from difluoromethyl phenyl sulfone and a base, was found to easily undergo nucleophilic substitution reactions (SN2) with primary alkyl halides, elemental halogens, and perfluoroalkyl halides with good selectivity. The formed (benzenesufonyl)difluoromethylalkanes are useful intermediates for the facile preparation of 1,1-difluoro-1-alkenes and difluoromethylalkanes. Thus, difluoromethyl phenyl sulfone acts as both “CF2═” and “CF2H−” synthons; 展开▼
机译：发现由二氟甲基苯基砜和碱原位生成的（苯磺酰基）二氟甲基阴离子与伯烷基卤化物，元素卤素和全氟烷基卤化物容易发生亲核取代反应（S N 2）选择性。形成的（苯磺酰基）二氟甲基烷烃是用于容易地制备1，1-二氟-1-烯烃和二氟甲基烷烃的有用中间体。因此，二氟甲基苯基砜既是“ CF 2 ═”又是“ CF 2 H -”合成子。 展开▼
