首页> 外国专利> Crystal structures of T. foetus inosine monophosphate dehydrogenase in complex with substrate, cofactor and analogs and uses thereof

Crystal structures of T. foetus inosine monophosphate dehydrogenase in complex with substrate, cofactor and analogs and uses thereof

机译:T的晶体结构。底物,辅因子和类似物复合的胎儿肌苷单磷酸脱氢酶及其用途

摘要

The invention provides a crystalline complex containing T. foetus IMPDH in complex with inosine monophosphate (IMP), the complex specified by disclosed atomic coordinates. Also provided are crystalline complexes of containing T. foetus IMPDH with both inosine monophosphate (IMP) and mycophenolic acid, with both xanthosine monophosphate (XMP) and mycophenolic acid, with both xanthosine monophosphate (XMP) and nicotinic adenine dinucleotide (NAD), with ribovirin (1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide, and with both ribovirin and mycophenolic acid, each complex specified by disclosed atomic coordinates. Also provided by the invention are the atomic coordinates for these complexes. Further provided by the invention are methods for identifying modulations of IMPDH that employ the atomic coordinates of the invention.
机译:本发明提供了包含I T的结晶络合物。胎儿 IMPDH与肌苷一磷酸(IMP)的复合物,该复合物由公开的原子坐标指定。还提供了含有I T的结晶配合物。胎儿 IMPDH既含肌苷一磷酸(IMP)和麦考酚酸,又含黄嘌呤单磷酸(XMP)和麦考酚酸,含黄嘌呤单磷酸(XMP)和烟碱腺嘌呤二核苷酸(NAD),含核糖蛋白(1-β- D-核呋喃糖基-1,2,4-三唑-3-羧酰胺,以及核糖病毒素和霉酚酸,各自的配合物均由公开的原子坐标指定,本发明还提供了这些配合物的原子坐标。是识别采用本发明原子坐标的IMPDH的调节的方法。

著录项

  • 公开/公告号US7083961B1

    专利类型

  • 公开/公告日2006-08-01

    原文格式PDF

  • 申请/专利权人 HARTMUT LUECKE;GLEN PROSISE;

    申请/专利号US20030663347

  • 发明设计人 GLEN PROSISE;HARTMUT LUECKE;

    申请日2003-09-15

  • 分类号C12N9/02;

  • 国家 US

  • 入库时间 2022-08-21 21:43:08

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