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DNA molecules encoding Macaca mulatta androgen receptor

机译：编码猕猴雄激素受体的DNA分子

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摘要

The present invention discloses the isolation and characterization of cDNA molecules encoding novel androgen receptor (AR) protein from Macaca mulatta. Also within the scope of the disclosure are recombinant vectors, recombinant host cells, methods of screening for modulators of Macaca mulatta AR (rhAR) activity, purified proteins and fusion proteins which comprise all or a portion of the rhAR protein, transgenic mice comprising a transgene encoding the rhAR protein, as well as production of antibodies against AR, or epitopes thereof. 展开▼

机译：本发明公开了从猕猴（Macaca mulatta）中编码新的雄激素受体（AR）蛋白的cDNA分子的分离和鉴定。也在本公开范围内的是重组载体，重组宿主细胞，筛选食蟹猕猴AR（rhAR）活性调节剂的方法，纯化的蛋白质和包含全部或部分rhAR的融合蛋白蛋白，包括编码rhAR蛋白的转基因的转基因小鼠，以及抗AR的抗体或其表位的产生。 展开▼

著录项

公开/公告号US7060463B2

专利类型

公开/公告日2006-06-13

原文格式PDF

申请/专利权人 DWIGHT A. TOWLER;FANG CHEN;
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申请/专利号US20030476724

发明设计人 DWIGHT A. TOWLER;FANG CHEN;
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申请日2002-05-03

分类号C12N15/11;C12N5/10;C12N15/63;

国家 US

入库时间 2022-08-21 21:43:58

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3. DNA MOLECULES ENCODING MACACA MULATTA ANDROGEN RECEPTOR [P] . 欧洲知识产权局专利： EP1392821A4 . 2005-01-26

机译：编码马卡达穆拉塔雄激素受体的DNA分子

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5. Dna molecules encoding macaca mulatta androgen receptor [P] . 美国专利： US2004254105A1 . 2004-12-16

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4. The effect of diet-induced insulin resistance on DNA methylation of the androgen receptor promoter in the penile cavernosal smooth muscle of mice [J] . Jin-Wook Kim, Mi-Mi Oh, Cheol-Yong Yoon, 亚洲男性学杂志（英文版） . 2013,第004期

5. Molecular dynamics and ab initio FMO calculations on the effect of water molecules on the interactions between androgen receptor and its ligand and cofactor [C] . Kanako Shimamura, Hiromi Ishimura, Ittetsu Kobayashi, International Conference on Advanced Informatics: Concepts, Theory and Applications . 2016

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7. Adrenal androgen concentrations increase during infancy in male rhesus macaques (Macaca mulatta) [O] . A. J. Conley, T. M. Plant, D. H. Abbott, -1

8. Sequence and expression of a cDNA encoding the red seabream androgen receptor1Accession number: AB017158 (Pagrus major androgen receptor).1 [O] . Touhata Ken, Kinoshita Masato, Tokuda Yuki, 1999

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