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Piracetam and piracetam analog conjugate and a pharmaceutical composition for treatment of neuronal disorders
Piracetam and piracetam analog conjugate and a pharmaceutical composition for treatment of neuronal disorders
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机译：吡乙酰胺和吡乙酰胺类似物偶联物以及用于治疗神经元疾病的药物组合物
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摘要
A compound of the formula where R1 is H, C1-C4 alkyl and OH; R2 in is H, C1-C4 alkyl and OH; R3 is H and C1-C4 alkyl; R4 is H and C1-C4 alkyl; n is an integer between 0 and 2 inclusive; R5 is a nullity, NHR7C(O)—, C6H4—, C6H4—O—; R7 is C2-C6 alkyl; and R6 is a moiety capable of crossing the blood brain barrier and is as a free compound serotonin, dopamine, blood brain barrier (BBB) peptide, membrane translocating peptide, TAT peptides, bradykinin, beta-endorphin, bombesin, calcitonin, cholecystokinin, an enkephalin, dynorphin, insulin, gastrin, substance P, neurotensin, glucagon, secretin, somatostatin, motilin, vasopressin, oxytocin, prolactin, thyrotropin, an angiotensin, galanin, neuropeptide Y, thyrotropin-releasing hormone, gonadotropnin-releasing hormone, growth hormone-releasing hormone, luteinizing hormone, vasoactive intestinal peptidegluconate, transferrin, glucosylamine, amino saccharin, saccharin ester, lactylamine, leucine, tryptophan, amino glutamate and amino cholines.
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机译：下式的化合物 <图像alt =“嵌入式图像” file =“ US20060142182A1-20060629-C00001.GIF” he =“ 25.91mm” id =“ EMI-C00001” imgContent =“ chem” imgFormat =“ GIF” wi =“ 63.25mm” /> 其中R 1 是H，C 1 -C 4 烷基和OH; R 2 in是H，C 1 -C 4 烷基和OH; R 3 是H和C 1 -C 4 烷基; R 4 是H和C 1 -C 4 烷基; n是介于0和2之间（含2和2）的整数; R 5 是无效的，NHR 7 C（O）-，C 6 H 4 -，C < Sub> 6 H 4 —O—; R 7 是C 2 -C 6 烷基;和R 6 是能够穿过血脑屏障的部分，是游离的血清素，多巴胺，血脑屏障（BBB）肽，膜移位肽，TAT肽，缓激肽，β-内啡肽，蛙皮素，降钙素，胆囊收缩素，脑啡肽，强啡肽，胰岛素，胃泌素，P物质，神经降压素，胰高血糖素，促胰液素，促生长素抑制素，胃动素，血管加压素，催产素，催乳素，促甲状腺素，血管紧张素，甘丙肽，神经肽Y，促性腺激素释放激素，生长激素释放激素，黄体生成激素，血管活性肠肽葡萄糖酸盐，转铁蛋白，葡糖胺，氨基糖精，糖精酯，乳糖胺，亮氨酸，色氨酸，氨基谷氨酸和氨基胆碱。
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