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Notoginseng saponin intravenous injection and the method for preparing this injection

机译:三七总皂苷静脉注射液及其制备方法

摘要

The invention shows the saponins family of Radix notoginshen intravenous injection, a method for preparation thereof. The object is to provide an intravenous injection for prevention and treatment of cardiac and cerebral vascular disease and its sequelae. This injection has stable pH, could be used in large dosage, and with main active component of saponins family of Radix notoginshen. The main components for this injection includes saponins family of Radix notoginshen with a concentration of 0.1 mg-14.0 mg (Rgl), iso-osmotic solution with a concentration of 7.5-9.6 mg/ml, and pH stabilizer with a concentration of 0.2-0.5 mg/ml. The solvent for said injection is distilled water. The method for preparation of the saponins family of Radix notoginshen intravenous injection includes: (1) dissolution of iso-osmotic solution in distilled water to a concentration of 50-300 mg/ml, and filtration through active carbon; (2) addition of the saponins family of Radix notoginshen intravenous injection to the filtrate to a concentration of 0.1 mg-14.0 mg (Rgl); (3) addition of pH stabilizer to the filtrate to a concentration of 0.2-0.5 mg/ml, filtration until clear, packaging and obtaining of the saponins family of Radix notoginshen intravenous injection.
机译:本发明显示了三七总皂苷静脉注射的皂苷家族及其制备方法。目的是提供用于预防和治疗心脑血管疾病及其后遗症的静脉内注射剂。该注射剂具有稳定的pH,可以大剂量使用,并且具有三七总皂苷家族的主要活性成分。 该注射剂的主要成分包括浓度为0.1 mg-14.0 mg(Rgl)的 Radix notoginshen 的皂苷家族,浓度为7.5-9.6 mg / ml的等渗溶液以及浓度为0.2-0.5 mg / ml的pH稳定剂。用于所述注射的溶剂是蒸馏水。三七总皂苷家族静脉注射液的制备方法包括:(1)将等渗溶液溶于蒸馏水中至浓度为50-300 mg / ml,并通过活性炭过滤; (2)将三七总皂苷的皂苷家族静脉内注射至滤液中,浓度为0.1mg-14.0mg(Rgl); (3)向滤液中添加pH稳定剂至浓度为0.2-0.5 mg / ml,过滤直至澄清,包装并获得静脉注射三七总皂苷家族。

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