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Activity measurement method and the specific substrate of von Willebrand factor-cleaving protease
Activity measurement method and the specific substrate of von Willebrand factor-cleaving protease
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机译:von Willebrand因子裂解蛋白酶的活性测定方法和特异性底物
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摘要
Diagnosis of ADAMTS-13-deficient patients using them as well as specific substrates, the von Willebrand factor-cleaving protease ADAMTS-13, the diagnostic composition, and the invention relates to kits. SEQ ID NO: of the Sequence Listing particularly preferred ADAMTS-13 substrate polypeptide: one that starts from amino acid 1 of 1587, ending at amino acid 1668, is one and start from amino acid 1596, ending ending at amino acid 1668. Substrate specificity is strongly ADAMTS-13 substrate polypeptides of these are sized to excellent quantitative properties, suitable for the production by recombinant methods.
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机译:使用ADAMTS-13缺陷型患者以及特定底物,von Willebrand因子裂解蛋白酶ADAMTS-13的诊断,诊断组合物,并且本发明涉及试剂盒。序列表的SEQ ID NO:特别优选的ADAMTS-13底物多肽:一种起始于1587的氨基酸1,终止于氨基酸1668的多肽,是一种起始于氨基酸1596,终止于氨基酸1668的多肽。它们是强烈的ADAMTS-13底物多肽,其大小适于优异的定量特性,适合通过重组方法生产。
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