首页> 外国专利> Cyclic palladium compounds coordinated with bis (diphenylphosphine) ferrocene ligands that inhibit the activity of proteins and enzymes and treatment of diseases and disorders related thereto

Cyclic palladium compounds coordinated with bis (diphenylphosphine) ferrocene ligands that inhibit the activity of proteins and enzymes and treatment of diseases and disorders related thereto

机译：与双（二苯基膦）二茂铁配体配位的环状钯化合物，可抑制蛋白质和酶的活性以及与之相关的疾病和障碍的治疗

页面导航

摘要
著录项
相似文献

摘要

The invention relates to cyclopalladated compounds containing bis-diphenyiphosphine-ferrocene ligands and their analogues which are active inhibitors of proteins and enzymes, for example, those of the serine peptidase, cysteine-protease, metalo-protease and endopeptidase families, involved in the development and metastases of malignant tumors, e.g. of the thyroid. An exemplary compound is shown in the figure. The compounds are able te modulate the immunological system due to their action on the enzymes and their interaction with DNA molecules.

机译：本发明涉及含有双-二苯基膦-二茂铁配体及其类似物的环palpalated化合物，它们是蛋白质和酶的活性抑制剂，例如丝氨酸肽酶，半胱氨酸蛋白酶，金属蛋白酶和内肽酶家族的抑制剂恶性肿瘤的转移，例如甲状腺。图中显示了示例性化合物。由于这些化合物对酶的作用以及与DNA分子的相互作用，因此它们能够调节免疫系统。

著录项

公开/公告号JP2006510584A

专利类型
公开/公告日2006-03-30

原文格式PDF
申请/专利权人フンダソンデアンパロアペスキサドエスタドデサンパウロ;
展开▼

申请/专利号JP20040531314
发明设计人カイレス;アントニオカルロスファーベロ;トリンダーデ;クラウディアビンコレット;テルサリオル;イバルネルイスドスサントス;
展开▼

申请日2003-08-22
分类号C07F19;A61K31/555;A61P43;A61P19/02;A61P21/04;A61P35;A61P13/12;A61P33;A61P1/02;A61P29;A61P11;A61P19/10;A61P1/18;A61P25/28;A61P25/24;A61P3/10;A61P33/02;A61P25/18;A61P25/32;A61P31/18;A61P25;A61P37/02;A61P9;A61P35/04;C07F17/02;C07F15;
国家 JP
入库时间 2022-08-21 21:51:06

相似文献

专利
外文文献
中文文献