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Controlled release systems for drugs, foods, and nutritional supplements

机译：药品，食品和营养补品的控释系统

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摘要

The present invention relates to an improved controlled release system that can encapsulate different flavors, sensory markers, and active ingredients, or combinations of flavors, sensory markers and various active ingredients and release multiple active ingredients in a consecutive manner, one after the other. The controlled delivery system of the present invention is substantially free-flowing powder formed of solid hydrophobic nanospheres that are encapsulated in a moisture sensitive microspheres. The flavors, and active ingredients encapsulated in the hydrophobic nanospheres, in the water sensitive microsphere, or in both the nano and the microsphere. The flavors and active ingredients encapsulated in the nanospheres can be the same or different from those encapsulated in the microspheres. The encapsulation of different flavors or active agents in the various components of the system, such as nanospheres and microspheres, provides flavor transition (change in flavor character) during the use of the products. The controlled release system of the present invention enhances the stability and bioavailability of wide range of flavors, sensory markers, and other active ingredients, prolong their residence time in the oral cavity, control their release characteristics, and prolong the sensation of flavors and other sensory markers in the mouth to provide long lasting organoleptic perception or long lasting mouthfeel. The invention further relates oral care, food products, and beverages comprising the controlled release system of the present invention.

机译：本发明涉及一种改进的控释系统，其可以包封不同的风味剂，感官标记物和活性成分，或风味剂，感官标记物和各种活性成分的组合，并以一种连续的方式依次释放多种活性成分。本发明的受控递送系统是由固体疏水性纳米球形成的基本上自由流动的粉末，所述固体疏水性纳米球被封装在对水分敏感的微球中。包封在疏水性纳米球，水敏感性微球或纳米和微球中的调味剂和活性成分。封装在纳米球中的调味剂和活性成分可以与封装在微球中的调味剂和活性成分相同或不同。将不同的调味剂或活性剂封装在系统的各种组件（例如纳米球和微球）中，可在产品使用过程中提供调味过渡（调味特性的变化）。本发明的控释系统增强了各种调味剂，感官标记和其他活性成分的稳定性和生物利用度，延长了它们在口腔中的停留时间，控制了它们的释放特性，并延长了调味剂和其他感官的感觉。口腔中的标记可提供持久的感官感觉或持久的口感。本发明进一步涉及包含本发明的控释系统的口腔护理，食品和饮料。

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公开/公告号JP2006523221A

专利类型
公开/公告日2006-10-12

原文格式PDF
申请/专利权人サルヴォナエルエルシー;
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申请/专利号JP20060508716
发明设计人シェファー;アディ;シェファー;サミュエル;
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申请日2004-02-11
分类号A61K9/14;A61K9/51;A61K47/44;A61K47/12;A61K47/32;A61K47/34;A61K47/36;A61K47/42;A61K47/38;A61K47/46;A61P3/02;A61P1/02;A61Q11;A61K8/92;A61K8/36;A61K8/37;A61K8/73;A61K8/64;A61K8/81;A61K8/84;A23G4;A23G3;A23G3/34;A23L1;A23L1/30;A23L1/39;A23L2/52;A23L2;A23L2/39;A61K31/355;
国家 JP
入库时间 2022-08-21 21:54:01

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