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NEW APPLICATION OF GLIOTOXIN AS ACTIVE INGREDIENT OF ANTIMALARIAL MEDICINE AND ANTIMALARIAL MEDICINE CONTAINING GLIOTOXIN AS ACTIVE INGREDIENT

机译：含草毒素作为活性成分的活性成分的新应用和含草毒素的活性成分的抗风湿药

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摘要

PPROBLEM TO BE SOLVED: To find an active ingredient as a new antimalarial medicine and clarify its action mechanism. PSOLUTION: Gliotoxin which is an antibiotic substance which fungal Aspergillus produces is used as an active ingredient for the antimalarial medicine. The antimalarial medicine contains gliotoxin as an active ingredient. Specifically, proteasome activity of Plasmodium spp. is inhibited by gliotoxin to exhibit antimalarial effect. Further, e.g. the gliotoxin is made to act as an active ingredient of antimalarial medicine against chloroquine-sensitive or resistant Plasmodium spp. When the gliotoxin is used, the concentration free from cytotoxicity can be selected. PCOPYRIGHT: (C)2006,JPO&NCIPI

机译：

要解决的问题：寻找一种有效成分作为一种新的抗疟疾药物，并阐明其作用机理。

解决方案：胶质毒素是一种由曲霉属真菌产生的抗生素，被用作抗疟药的活性成分。该抗疟药含有葡聚糖毒素作为有效成分。具体而言，疟原虫属物种的蛋白酶体活性。被胶体毒素抑制，表现出抗疟作用。此外，例如葡聚糖毒素被用作对抗氯喹敏感或耐药的疟原虫的抗疟药物的活性成分。当使用神经毒素时，可以选择无细胞毒性的浓度。

版权：（C）2006，JPO＆NCIPI 展开▼

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公开/公告号JP2006249019A

专利类型
公开/公告日2006-09-21

原文格式PDF
申请/专利权人 GUNMA UNIV;PRIME DELTA KK;
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申请/专利号JP20050069560
发明设计人 SATO KUMIKO;HATAO TOSHIMITSU;HAGIWARA MASAKI;KIYOZAWA MASAYUKI;SUZUKI MAMORU;
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申请日2005-03-11
分类号A61K31/548;A61P33/06;A61P43;C07D513/20;
国家 JP
入库时间 2022-08-21 21:56:30

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