PPROBLEM TO BE SOLVED: To provide an RNA interference polynucleotide mixture having a wide and high effectiveness against pathogenic microorganisms having high genome polymorphism and frequently generating mutation. PSOLUTION: This device 20 for designing the RNA interference polynucleotide mixture is provided by obtaining a multiple number of sequence information on the genome, its transcription products or their specific partial sequences of HIV-1, also obtaining a multiple number of base sequence information of target sites based on the above information, and obtaining a multiple number of base sequence information on siRNAs (short interfering RNAs) against the target sites based on the base sequence information of the target sites. From the obtained siRNAs, a more preferable combination capable of coping with the genome polymorphism and generation of the mutations of the HIV is selected. The selection of the combination is performed based on the comprehensibility associated with the possibility of the combination of the siRNAs capable of performing the RNA interference with how many sequence information of the HIV, and redundancy associated with how many siRNAs can perform the RNA interference with one information of the HIV-1 sequence information among the combinations. PCOPYRIGHT: (C)2006,JPO&NCIPI
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