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Novel vitamin B12 - biodegradable micro particulate conjugate carrier systems for peroral delivery of drugs, therapeutic peptides/proteins and vaccines

机译：新型维生素B12-可口服递送药物，治疗性肽/蛋白质和疫苗的可生物降解的微粒结合物载体系统

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摘要

The invention relates to a novel complex for oral delivery of drugs, therapeutic protein/peptides and vaccines which are loaded in a Vitamin B12 (VB12) coupled particulate carrier system with spacers in between, the carrier system with spacers having a formula VB12-R'/R''-N wherein, R' or R'' is spacer and/or agents for derivatization of VB12 to provide either NH2 or COOH or SH groups, and N is the micro or nano particle carriers for the delivery of injectable drugs, therapeutic protein/peptides and vaccines.

机译：本发明涉及用于口服递送药物，治疗性蛋白质/肽和疫苗的新型复合物，所述复合物被装载在维生素B12（VB12）偶联的颗粒载体系统中，所述载体之间具有间隔物，所述载体系统具有式VB12-R'的间隔物。 / R''-N，其中，R'或R''是间隔基和/或用于VB12衍生化以提供NH2或COOH或SH基团的试剂，N是用于递送可注射药物的微米或纳米颗粒载体，治疗性蛋白质/肽和疫苗。

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公开/公告号GB2374010B

专利类型
公开/公告日2004-12-29

原文格式PDF
申请/专利权人 * COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH;
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申请/专利号GB20020007457
发明设计人 KISHORE BABU * CHALASANI;PRAKASH VAMANRAO * DIWAN;KONDAPURAM VIJAYA * RAGHAVAN;GREGORY JOHN * RUSSELL-JONES;SANJAIN KUMAR * JAIN;KOLLIPARA KOTESHAWAR * RAO;
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申请日2001-02-26
分类号A61K47/48;A61K9/16;A61K9/51;A61P3/10;
国家 GB
入库时间 2022-08-21 21:57:48

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