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Isolated cytotoxic factor associated with plate sclerosis in humans is selected from GM2AP/GM2/MRP14 hetero-complex and detected by capture antibody
Isolated cytotoxic factor associated with plate sclerosis in humans is selected from GM2AP/GM2/MRP14 hetero-complex and detected by capture antibody
The cytotoxic factor is selected from the GM2AP/GM2/MRP14 and mutated GM2AP/GM2/MRP14 hetero-complex in which the mutated GM2AP corresponds to the SEQ ID NO :2 sequence. The detection and/or quantification of such a cytotoxic factor is carried out with a biological sample which is placed in contact with a capture antibody from those which bond specifically with the following proteins or complexes. The cytotoxic factor is selected from the GM2AP/GM2/MRP14 and mutated GM2AP/GM2/MRP14 hetero-complex in which the mutated GM2AP corresponds to the SEQ ID NO :2 sequence. The detection and/or quantification of such a cytotoxic factor is carried out with a biological sample which is placed in contact with a capture antibody from those which bond specifically with the following proteins or complexes: GM2AP, mutated GM2AP, MRP14, the GM2AP/GM2 complex, the mutated GM2AP/GM2 complex, and the MRP14?GM2 complex, where the mutated GM2AP corresponds to the SEQ ID NO :2 sequence. The sample is then placed in contact with a marked detection antibody selected from those that bond specifically with the above proteins, and the cytotoxic factor is detected and/or quantified by detection and/or quantification of the marked detection antibody.
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机译：细胞毒性因子选自GM2AP / GM2 / MRP14和突变的GM2AP / GM2 / MRP14异源复合物，其中突变的GM2AP对应于SEQ ID NO：2序列。用生物样品进行这种细胞毒性因子的检测和/或定量，该生物样品与与下列蛋白或复合物特异性结合的抗体中的捕获抗体接触。细胞毒性因子选自GM2AP / GM2 / MRP14和突变的GM2AP / GM2 / MRP14异源复合物，其中突变的GM2AP对应于SEQ ID NO：2序列。此类细胞毒性因子的检测和/或定量是通过将生物样品与捕获抗体接触而进行的，该捕获抗体来自与以下蛋白质或复合物特异性结合的抗体：GM2AP，突变的GM2AP，MRP14，GM2AP / GM2复合体，突变的GM2AP / GM2复合体和MRP14→GM2复合体，其中突变的GM2AP对应于SEQ ID NO：2序列。然后使样品与选自与上述蛋白质特异性结合的那些的标记的检测抗体接触，并且通过检测和/或定量标记的检测抗体来检测和/或定量细胞毒性因子。
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