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PRODUCTION OF LIPID NUCLEAR PARTICLES BY A HYDROPHOBIC LIPID NUCLEAR ACID COMPLEX BY-PRODUCT AND FOR USE IN THE GENTRANSFER
PRODUCTION OF LIPID NUCLEAR PARTICLES BY A HYDROPHOBIC LIPID NUCLEAR ACID COMPLEX BY-PRODUCT AND FOR USE IN THE GENTRANSFER
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机译:疏水性脂质核酸复合物副产物生产脂质核颗粒并用于遗传转移
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摘要
Novel lipid-nucleic acid particulate complexes which are useful for in vitro or in vivo gene transfer are described. The particles can be formed using either detergent dialysis methods or methods which utilize organic solvents. Upon removal of a solubilizing component (i.e. detergent or an organic solvent) the lipid-nucleic acid complexes form particles wherein the nucleic acid is serum-stable and is protected from degradation. The particles thus formed have access to extravascular sites and target cell populations and are suitable for the therapeutic delivery of nucleic acids.
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