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Synergistic effect of glyburide and milrinone

机译：格列本脲与米力农的协同作用

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摘要

The invention relates to the use of a synergistic amount of: 1) a sulfonylurea, a non-sulfonylurea K+ ATP channel blocker, or a sulfonylurea and a non-sulfonylurea K+ ATP channel blocker; and 2) a cAMP phosphodiesterase type 3 inhibitor; for the manufacture of medicaments for treating or preventing non-insulin dependent diabetes mellitus, insulin resistance, Syndrome X, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic cardiomyopathy, polycystic ovary syndrome, cataracts, hyperglycemia, or impaired glucose tolerance. The present invention also provides kits and pharmaceutical compositions that comprise: 1) a sulfonylurea, a non-sulfonylurea K+ATP channel blocker, or a sulfonylurea and a non-sulfonylurea K+ ATP channel blocker: and 2) a cAMP phosphodiesterase type 3 inhibitor. The present invention also relates to kits and pharmaceutical compositions that comprise 1) a sulfonylurea, a non-sulfonylurea K+ ATP channel blocker, or a sulfonylurea and a non-sulfonylurea K+ ATP channel blocker: 2) a cAMP phosphodiesterase type 3 inhibitor; and 3) an additional compound useful for the treatment of non-insulin dependent diabetes mellitus, insulin resistance, Syndrome X, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic caridomyopathy, polycystic ovary syndrome, cataracts, hyperglycermia, or impaired glucose tolerance.

机译：本发明涉及协同量的用途：1）磺酰脲，非磺酰脲K + ATP通道阻滞剂，或磺酰脲和非磺酰脲K + ATP通道阻滞剂; 2）cAMP 3型磷酸二酯酶抑制剂;用于制造用于治疗或预防非胰岛素依赖型糖尿病，胰岛素抵抗，X综合征，糖尿病性神经病，糖尿病性肾病，糖尿病性视网膜病，糖尿病性心肌病，多囊卵巢综合征，白内障，高血糖症或糖耐量降低的药物。本发明还提供了试剂盒和药物组合物，其包含：1）磺酰脲，非磺酰脲K + ATP通道阻滞剂或磺酰脲和非磺酰脲K + ATP通道阻滞剂;和2）cAMP磷酸二酯酶3型抑制剂。本发明还涉及试剂盒和药物组合物，其包含1）磺酰脲，非磺酰脲K + ATP通道阻滞剂，或磺酰脲和非磺酰脲K + ATP通道阻滞剂：2）cAMP磷酸二酯酶3型抑制剂; 3）用于治疗非胰岛素依赖型糖尿病，胰岛素抵抗，X综合征，糖尿病性神经病，糖尿病性肾病，糖尿病性视网膜病，糖尿病性颈椎病，多囊卵巢综合症，白内障，高血糖症或糖耐量降低的另外的化合物。

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公开/公告号DE60103203T2

专利类型
公开/公告日2005-05-04

原文格式PDF
申请/专利权人 PFIZER PRODUCTS INC. GROTON CONN. US;
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申请/专利号DE60103203
发明设计人 FRYBURG DAVID ALBERT GROTON CONNECTICUT 06340 US;PARKER JANICE CATHERINE GROTON CONNECTICUT 06340 US;
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申请日0000-00-00
分类号A61K31/64;A61K31/4545;A61P3/10;
国家 DE
入库时间 2022-08-21 21:59:33

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