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首页> 外国专利> Diagnosis of pancreatic cancer by detecting expression of the a disintegrin and metalloprotease domain 9 (ADAM9) protein using specific antibodies, also therapeutic use of these antibodies and of ADAM9-specific nucleic acids

Diagnosis of pancreatic cancer by detecting expression of the a disintegrin and metalloprotease domain 9 (ADAM9) protein using specific antibodies, also therapeutic use of these antibodies and of ADAM9-specific nucleic acids

机译：通过使用特异性抗体检测整合素和金属蛋白酶结构域9（ADAM9）蛋白的表达来诊断胰腺癌，以及这些抗体和ADAM9特异性核酸的治疗用途

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摘要

Method for diagnosing pancreatic tumors by determining expression of the ADAM9 protein (a disintegrin and metalloprotease domain 9). Isolated cells or tissue sections of pancreas are incubated with ADAM9-specific antibodies (Ab) then examined under a microscope for binding of Ab. Independent claims are also included for the following: (1) Ab, for diagnosis of pancreatic tumors, that are bound to a marker, preferably a radioisotope such as technetium-99, that enables representation by tomographic or scintigraphic methods; (2) Ab, bound to a cell-killing agent, for treating pancreatic tumors; (3) use of nucleic acid (I), or its derivatives, specific for the ADAM9 gene, or its RNA, for treating pancreatic tumors; and (4) nucleic acid sequences (II), or their derivatives, having any of the 26 fully defined sequences of 20-23 nucleotides in length (SEQ ID Nos: 1-26) as given in the specification. An example of the sequences (SEQ ID Nos: 1-3) are as follows: GTTCCTGTGG AGCAAAGAGC CCAGCGTCCA CCAACTTATT GCATTTGTGG GAACAGTGTG ACTIVITY : Cytostatic. No details of tests for cytostatic activity are given. MECHANISM OF ACTION : Gene therapy; Immunotoxin; Radioimmunotherapeutic.
机译：通过确定ADAM9蛋白（整合素和金属蛋白酶结构域9）的表达来诊断胰腺肿瘤的方法。将分离的胰腺细胞或胰腺组织切片与ADAM9特异性抗体（Ab）孵育，然后在显微镜下检查Ab的结合。还包括以下方面的独立权利要求：（1）Ab，用于诊断胰腺肿瘤，其与标记物结合，所述标记物优选能够通过层析或闪烁显像法进行表征的标记物，优选放射性同位素如tech- 99。 （2）与细胞杀伤剂结合的抗体，用于治疗胰腺肿瘤; （3）对ADAM9基因或其RNA具有特异性的核酸（I）或其衍生物在治疗胰腺肿瘤中的用途; （4）核酸序列（II）或其衍生物，其具有说明书中给出的长度为20-23个核苷酸的26个完全定义的序列中的任一个（SEQ ID Nos：1-26）。序列的一个例子（SEQ ID Nos：1-3）如下：GTTCCTGTGG AGCAAAGAGC CCAGCGTCCA CCAACTTATT GCATTTGTGG GAACAGTGTG活性：细胞静止的。没有给出细胞抑制活性测试的细节。作用机理：基因治疗;免疫毒素放射免疫治疗。

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