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PTH PTHrp A process for the synthesis of analogs of parathyroid hormone PTH and parathyroid hormone related peptide PTHrp
PTH PTHrp A process for the synthesis of analogs of parathyroid hormone PTH and parathyroid hormone related peptide PTHrp
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机译：PTH PTHrp甲状旁腺激素PTH和甲状旁腺激素相关肽PTHrp类似物的合成方法
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摘要
Parathyroid hormone (PTH), parathyroid hormone related peptide (PTHrp), and synthetic polypeptide analogs of the cleaved physiologically active homologs and analogs of PTH and PTHrp, and pharmaceutically acceptable salts thereof, wherein Haa (Laa Laa Haa Haa) Amino acid residues (22-31) selected from lipophilic amino acids (Laa) and hydrophilic amino acids (Haa) arranged in 2 Laa order form amphoteric α-helices) for the treatment of mammalian osteoporosis and It is useful for prevention. Methods of making this polypeptide by solid phase methods and recombinant methods are provided.
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