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MEDICAMENT COMPOSITION FOR PREVENTION AND TREATMENT OF ANALGESIC TOLERANCE TO MORPHINE COMPRISING BERBERINE AS EFFECTIVE COMPONENT WHICH CONTRIBUTES TO MAINTAIN INITIAL PAIN-RELIEVING ACTIVITY OF MORPHINE DURING REPEATED ADMINISTRATION OF MORPHINE
MEDICAMENT COMPOSITION FOR PREVENTION AND TREATMENT OF ANALGESIC TOLERANCE TO MORPHINE COMPRISING BERBERINE AS EFFECTIVE COMPONENT WHICH CONTRIBUTES TO MAINTAIN INITIAL PAIN-RELIEVING ACTIVITY OF MORPHINE DURING REPEATED ADMINISTRATION OF MORPHINE
PURPOSE: A medicament composition for prevention and treatment of analgesic tolerance to morphine comprising berberine as an effective component is provided, which medicament composition contributes to maintain initial pain-relieving activity of morphine during the repeated administration period of morphine. CONSTITUTION: The medicament composition for prevention and treatment of analgesic tolerance to morphine comprises berberine as an effective component and pharmaceutically acceptable carriers, wherein the berberine is 7, 8, 13, 13a-tetrahydro- 9,10-dimethoxy-2,3-(methylenedioxy)berberium; the berberine is extracted from the root of Coptis japonica or cortex of Phellodendron amurense; LD50 of berberine is 90 mg/kg in rat; and the medicament composition is administered orally or through an injection.
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