首页> 外国专利> METHOD FOR IDENTIFYING A SITE OF PROTEIN-PROTEIN INTERACTION FOR THE RATIONAL DESIGN OF SHORT PEPTIDES THAT INTERFERE WITH THAT INTERACTION

METHOD FOR IDENTIFYING A SITE OF PROTEIN-PROTEIN INTERACTION FOR THE RATIONAL DESIGN OF SHORT PEPTIDES THAT INTERFERE WITH THAT INTERACTION

机译：蛋白质-蛋白质相互作用位点的鉴定方法，用于合理设计相互作用的短肽

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摘要

The invention provides a method for identifying a site of protein-protein interaction in a polypeptide. In general, the method involves calculating the difference in property scores between amino acids of a corresponding pair of amino acids on two homologous polypeptides, and identifying a window of contiguous amino acids that have a significant difference in property scores. The contiguous amino acids are predicted to be sites of protein-protein interactions. The invention provides computer systems for performing the methods. The subject methods and computer systems find application in identifying modulators of protein-protein interactions that can serve as inhibitors or activators of the protein from which it was derived, and, as such, find use in a variety or medical and research applications, including drug discovery.

机译：本发明提供了鉴定多肽中蛋白质-蛋白质相互作用的位点的方法。通常，该方法涉及计算两个同源多肽上的相应氨基酸对的氨基酸之间的特性得分之间的差异，以及鉴定在特性得分上具有显着差异的连续氨基酸的窗口。连续的氨基酸被预测为蛋白质-蛋白质相互作用的位点。本发明提供了用于执行所述方法的计算机系统。本发明的方法和计算机系统可用于鉴定蛋白质-蛋白质相互作用的调节剂，所述调节剂可用作蛋白质来源的蛋白质的抑制剂或活化剂，并因此可用于包括药物在内的多种或医学和研究应用中发现。

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公开/公告号WO2005084193A2

专利类型
公开/公告日2005-09-15

原文格式PDF
申请/专利权人 THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY;BRANDMAN RELLY;MOCHLY-ROSEN DARIA;
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申请/专利号WO2005US04882
发明设计人 BRANDMAN RELLY;MOCHLY-ROSEN DARIA;
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申请日2005-02-15
分类号G06F17/11;G06F17/50;G06F19/00;
国家 WO
入库时间 2022-08-21 22:08:50

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