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RHEUMATOID ARTHRITIS DISEASE SENSITIVE GENE, ITS PROTEIN, METHOD AND KIT OF JUDGING THE ONSET OF RHEUMATOID ARTHRITIS USING THE SAME, AND METHOD AND DRUGS FOR TREATING RHEUMATOID ARTHRITIS
RHEUMATOID ARTHRITIS DISEASE SENSITIVE GENE, ITS PROTEIN, METHOD AND KIT OF JUDGING THE ONSET OF RHEUMATOID ARTHRITIS USING THE SAME, AND METHOD AND DRUGS FOR TREATING RHEUMATOID ARTHRITIS
A rheumatoid arthritis disease sensitivity gene (I) encoding Angiopoietin-1 protein having a fully defined sequence of 498 amino acids (S1), given in the specification which has a glycine insertion variation at position 269, is new. Independent claims are included for the following: (1) protein (II) consisting of (S1) and a glycine insertion variation at the 269 position of the sequence; (2) determining the onset of rheumatoid arthritis; (3) determining the onset of rheumatoid arthritis by detecting the presence or absence of (I) or (II), or by using determination kit; (4) treating rheumatoid arthritis; and (5) therapeutic drug used for treatment of rheumatoid arthritis in a patient who has (II). ACTIVITY : Antirheumatic; Antiarthritic. No biological data is given. MECHANISM OF ACTION : Angiopoietin-1 protein agonist; Gene therapy.
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